1092961-07-3

Basic information

• Product Name: 4-Fluoro-1-methylindazole
• Synonyms: 4-Fluoro-1-methylindazole;1H-INDAZOLE, 4-FLUORO-1-METHYL-;4-Fluoro-1-methyl-1H-indazole
• CAS NO: 1092961-07-3
• Molecular Formula: C8H7FN2
• Molecular Weight: 150.1529832
• Product Categories: Building Blocks;Indazole
• Mol File: 1092961-07-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 236.1 °C at 760 mmHg
• Flash Point: 96.6 °C
• Appearance: /
• Density: 1.23 g/cm³
• Storage Temp.: 2-8°C
• PKA: 0.76±0.30(Predicted)
• CAS DataBase Reference: 4-Fluoro-1-methylindazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-1-methylindazole(1092961-07-3)
• EPA Substance Registry System: 4-Fluoro-1-methylindazole(1092961-07-3)

Safety Data

• Hazardous Substances Data: 1092961-07-3(Hazardous Substances Data)

Usage

General Description

4-Fluoro-1-methylindazole is a chemical compound that belongs to the class of indazoles, which are bicyclic aromatic heterocycles. It is characterized by the presence of a fluoro group and a methyl group attached to the indazole ring structure. 4-Fluoro-1-methylindazole has potential applications in pharmaceutical research, particularly in the development of new drugs and therapeutic agents. Its specific properties and biological activities are of interest to researchers in the field of medicinal chemistry, as it may exhibit pharmacological effects that could be relevant for the treatment of various diseases. Research on 4-Fluoro-1-methylindazole and its derivatives is ongoing to explore its potential as a drug candidate.

Upstream product

• 341-23-1 4-fluoro-1H-indazole 
• 74-88-4 methyl iodide 
• 365427-30-1 4-bromo-1-methyl-1H-indazole 
• 162502-44-5 3-amino-1-methyl-4-fluoro-1H-indazole 
• 1897-52-5 2,6 difluorobenzonitrile 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

A method for the regioselective synthesis of 1-alkyl-1H-indazoles

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles follo