1093115-84-4

Basic information

• Product Name: N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester
• Synonyms: N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester
• CAS NO: 1093115-84-4
• Molecular Weight: 1267.48
• Mol File: 1093115-84-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester(1093115-84-4)
• EPA Substance Registry System: N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine tert-butyl ester(1093115-84-4)

Safety Data

• Hazardous Substances Data: 1093115-84-4(Hazardous Substances Data)

Upstream product

• 383912-99-0 FmocAsp(OBt)OBu^t 
• 129460-09-9 Fmoc-Asp-O-t-Bu 

Downstream Products

• 1019849-43-4 N^α-(9-fluorenylmethoxycarbonyl)-N^γ-[(2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine 

Relevant articles and documents

Synthesis and antibacterial activities of N-Glycosylated derivatives of tyrocidine a, a macrocyclic peptide antibiotic

An efficient and practical method for macrocyclic glycopeptide synthesis was developed and utilized to synthesize tyrocidine A and its glycosylated derivatives. The method is based on solid-phase peptide synthesis using 2-chlorotrityl resin as the solid-phase support and glycosyl amino acids as building blocks. After glycopeptides with fully protected glycans and side chains were released from the acid-labile resin, their Cand N-termini were intramolecularly coupled in solution to afford cyclic glycopeptides in quantitative yields. This synthetic method should be generally applicable to various macrocyclic glycopeptides. Biological studies of the synthetic tyrocidine A derivatives showed that linking glycans directly to the Asn residue of tyrocidine A diminished its antibacterial activity, but linking glycans to Asn via a simple spacer did not. These results Revealed the important impact of glycans on the activities, and probably the structures, of glycopeptide antibiotics.