1093124-37-8Relevant articles and documents
Synthesis of CD-ring structure of cortistatin A, an anti-angiogenic steroidal alkaloid from marine sponge
Kotoku, Naoyuki,Sumii, Yuji,Hayashi, Takeshi,Kobayashi, Motomasa
body text, p. 7078 - 7081 (2009/04/07)
Stereoselective synthesis of the CD-ring structure of cortistatin A (1), a novel anti-angiogenic steroidal alkaloid from Indonesian marine sponge, was achieved. The stereogenic tertiary carbon center bearing the isoquinoline moiety was constructed by 1,3-chiral transfer method using Johnson-Claisen rearrangement of the chiral allylic alcohol 5. Subsequent intramolecular Michael-aldol reaction afforded the targeted trans-hydrindane skeleton with moderate stereoselectivity.