1093397-19-3

Basic information

• Product Name: 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)benzamide
• Synonyms: 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)benzamide
• CAS NO: 1093397-19-3
• Molecular Weight: 518.538
• Mol File: 1093397-19-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)benzamide(1093397-19-3)
• EPA Substance Registry System: 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)-N-({1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methyl)benzamide(1093397-19-3)

Safety Data

• Hazardous Substances Data: 1093397-19-3(Hazardous Substances Data)

Upstream product

• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 942216-18-4 {1-[4-(trifluoromethyl)phenyl]piperidin-4-yl}methanamine 
• 1093397-20-6 lithium 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)benzoate 
• 1093397-18-2 methyl 4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)benzoate 
• 1093395-69-7 [1-(4-trifluoromethyl-phenyl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester 
• 455-13-0 4-Iodobenzotrifluoride 
• 135632-53-0 tert-butyl N-(4-piperidinylmethyl)carbamate 
• 849353-44-2 4-hydroxy-3-methyl-5-nitro-benzonitrile 
• 1689-89-0 nitroxynil 
• 942215-54-5 3-amino-4-hydroxy-5-methylbenzonitrile 
• 1093565-24-2 C₁₆H₁₀N₂O₃ 

Downstream Products

• 1292821-35-2 C₃₀H₂₇F₃N₄O₂ 

Relevant articles and documents

2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Scaffold design and advancement in HDLc-raising efficacy

The development of 2-phenylbenzoxazoles as inhibitors of cholesteryl ester transfer protein (CETP) is described. Initial efforts aimed at engineering replacements for the aniline substructures in the benchmark molecule. Reversing the connectivity of the central aniline lead to a new class of 2-(4-carbonylphenyl)benzoxazoles. Structure-activity studies at the C-7 and terminal pyridine ring allowed for the optimization of potency and HDLc-raising efficacy in this new class of inhibitors. These efforts lead to the discovery of benzoxazole 11v, which raised HDLc by 24 mg/dl in our transgenic mouse PD model.