109346-95-4 Usage
General Description
2-(3,5-dichlorophenyl)acetaldehyde is a chemical compound with the molecular formula C8H6Cl2O. It is an aldehyde, which is a type of organic compound with a carbonyl group attached to a hydrogen atom and an R group. This particular aldehyde contains two chlorine atoms and a phenyl group attached to the carbonyl carbon. It is used in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of other organic compounds. 2-(3,5-dichlorophenyl)acetaldehyde is known for its strong and distinct odor and is considered to be an irritant to the skin, eyes, and respiratory system. It is important to handle this chemical with care and in accordance with proper safety protocols.
Check Digit Verification of cas no
The CAS Registry Mumber 109346-95-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,3,4 and 6 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 109346-95:
(8*1)+(7*0)+(6*9)+(5*3)+(4*4)+(3*6)+(2*9)+(1*5)=134
134 % 10 = 4
So 109346-95-4 is a valid CAS Registry Number.
109346-95-4Relevant articles and documents
Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis
Zhang, Yinan,Zhao, Kevin Tianmeng,Fox, Susan G.,Kim, Jinho,Kirsch, Donald R.,Ferrante, Robert J.,Morimoto, Richard I.,Silverman, Richard B.
, p. 5942 - 5949 (2015)
Pyrazolone derivatives have previously been found to be inhibitors of Cu/Zn superoxide dismutase 1 (SOD1)-dependent protein aggregation, which extended survival of an amyotrophic lateral sclerosis (ALS) mouse model. On the basis of ADME analysis, we describe herein a new series of tertiary amine-containing pyrazolones and their structure-activity relationships. Further conversion to the conjugate salts greatly improved their solubility. Phosphate compound 17 exhibited numerous benefits both to cellular activity and to CNS-related drug-like properties in vitro and in vivo, including microsomal stability, tolerated toxicity, and blood-brain barrier permeation. These results indicate that tertiary amine pyrazolones comprise a valuable class of ALS drug candidates.
