1094100-06-7

Basic information

• Product Name: (3R,5R)-Rosuvastatin
• Synonyms: (3R,5R)-Rosuvastatin;(3R,5R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid;Rosuvastatin (3R,5R)-IsoMer CalciuM;(3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;monocalcium mono((3R,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate);(3R,5R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl (methyl sulfonyl) amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid calcium salt
• CAS NO: 1094100-06-7
• Molecular Formula: C₂₂H₂₈FN₃O₆S
• Molecular Weight: 481.54
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 1094100-06-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 59-61°C
• Appearance: /
• Density: 1.368
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: (3R,5R)-Rosuvastatin(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5R)-Rosuvastatin(1094100-06-7)
• EPA Substance Registry System: (3R,5R)-Rosuvastatin(1094100-06-7)

Safety Data

• Hazardous Substances Data: 1094100-06-7(Hazardous Substances Data)

Usage

Description

(3R,5R)-Rosuvastatin, also known as Rosuvastatin Anti Isomer, is an enantiomer of Rosuvastatin (R700500). It is an off-white solid and is used for the treatment, prevention, and combination therapy of lipid-related disorders.

Uses

Used in Pharmaceutical Industry:
(3R,5R)-Rosuvastatin is used as an antilipemic agent for the treatment, prevention, and combination therapy of lipid-related disorders. It helps in managing high cholesterol and triglyceride levels, reducing the risk of cardiovascular diseases.

Upstream product

• 355806-00-7 rosuvastatin tert-butyl ester 
• 289042-12-2 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester 

Relevant articles and documents

Synthesis method of chiral isomer impurities of rosuvastatin calcium

The invention relates to a synthesis method of chiral isomer impurities of rosuvastatin calcium. The invention finds that meso compounds IV (3R, 5R) and (3R, 5S), which are obtained after a compound III is reduced by sodium borohydride, differ greatly in chemical properties, (3R, 5S) compounds, adopting hydroxyl cis-structures, on C-3 and C-5 can be hydrolyzed in a very low-temperature alkaline environment, while (3R, 5R) compounds, adopting hydroxyl trans-structures, on the C-3 and the C-5 can be hydrolyzed at a relatively high temperature and cannot be hydrolyzed at a low temperature, and by virtue of a peculiar phenomenon, two chiral isomers of the meso compound IV are separated to obtain a target compound. The synthesis method is short in route; chiral carbon is not required to be introduced from a side chain source; the synthesis method is simple in process and easy to operate; the purity and the yield of the obtained target product are high, the purity can reach 98.8%, the yield can reach 75%, and the purity and the yield are much higher than those in the prior art; a reference substance is provided for the (3R, 5S) chiral isomer impurities of the rosuvastatin calcium; the synthesis method is of a great significance in researching the quality of the rosuvastatin calcium.