109418-64-6

Basic information

• Product Name: N,N-bis(3-phenylpropyl)acetamide
• Synonyms: N,N-bis(3-phenylpropyl)acetamide
• CAS NO: 109418-64-6
• Molecular Weight: 295.425
• Mol File: 109418-64-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-bis(3-phenylpropyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(3-phenylpropyl)acetamide(109418-64-6)
• EPA Substance Registry System: N,N-bis(3-phenylpropyl)acetamide(109418-64-6)

Safety Data

• Hazardous Substances Data: 109418-64-6(Hazardous Substances Data)

Upstream product

• 692263-13-1 C₂₀H₂₁NO 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 6296-61-3 N,N-diallylacetamide 
• 100-42-5 styrene 
• 1184-78-7 trimethylamine-N-oxide 
• 108-24-7 acetic anhydride 

Downstream Products

• 150-59-4 alverine 

Relevant articles and documents

Construction of 3-arylpropylamines using Heck arylations. the total synthesis of cinacalcet hydrochloride, alverine, and tolpropamine

New synthetic routes toward the commercial drugs cinacalcet hydrochloride, alverine, and tolpropamine were developed using a Heck-Matsuda arylation as the key-step. Several reaction conditions were evaluated for the Heck-Matsuda reaction using allylamine derivatives and arenediazonium salts. For cinacalcet hydrochloride, N-formylamide provided the best result, furnishing the synthetic target in a very high overall yield (75% over five steps). For alverine, the best results were obtained using a double Heck-Matsuda strategy, providing alverine in an excellent overall yield (69%) from N-acetyl diallylamine in three steps. Tolpropamine was synthesized in a 46% yield over five steps using an efficient reductive Heck-Matsuda arylation between p-bromo-methylcinnamate with 3-chloro tolyldiazonium salt, generating the ,diaryl propionate that was converted to tolpropamine.