1094216-86-0Relevant articles and documents
Direct organocatalytic Mannich reaction of acetaldehyde: An improved catalyst and mechanistic insight from a computational study
Hayashi, Yujiro,Okano, Tsubasa,Itoh, Takahiko,Urushima, Tatsuya,Ishikawa, Hayato,Uchimaru, Tadafumi
supporting information; experimental part, p. 9053 - 9058 (2009/02/08)
(Chemical Equation Presented) A chiral diaryl prolinol silyl ether organocatalyst with an acidis used for the direct catalytic asymmetric Mannich reaction of acetaldehyde and imines. N-Benzoyl-, N-tert-butoxycarbonyl-, and N-toluene-4-sulfonylimines can be employed to produce synthetically useful β-amino aldehydes in goodyield s andwith excellent enantioselectivity (see scheme). The reaction mechanism was investigated quantum-mechanically.
