109471-14-9

Basic information

• Product Name: 2'-hydroxy-4'-(methoxymethoxy)-4-methoxychalcone
• Synonyms: 2'-hydroxy-4'-(methoxymethoxy)-4-methoxychalcone
• CAS NO: 109471-14-9
• Molecular Weight: 314.338
• Mol File: 109471-14-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2'-hydroxy-4'-(methoxymethoxy)-4-methoxychalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-hydroxy-4'-(methoxymethoxy)-4-methoxychalcone(109471-14-9)
• EPA Substance Registry System: 2'-hydroxy-4'-(methoxymethoxy)-4-methoxychalcone(109471-14-9)

Safety Data

• Hazardous Substances Data: 109471-14-9(Hazardous Substances Data)

Upstream product

• 108-46-3 recorcinol 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 1311271-71-2 (Z)-2-(4-methoxybenzylidene)-6-(methoxymethoxy)benzo[b]furan-3-one 
• 1311271-89-2 (Z)-2-(4-methoxybenzylidene)-3-oxo-2,3-dihydrobenzofuran-6-yl (10E,12Z)-linoleate 
• 1311272-02-2 (Z)-2-(4-methoxybenzylidene)-3-oxo-2,3-dihydrobenzofuran-6-yl stearate 
• 1311272-16-8 (Z)-2-(4-methoxybenzylidene)-3-oxo-2,3-dihydrobenzofuran-6-yl 10-undecylenate 
• 20727-61-1 (2Z)-6-hydroxy-2-(4-methoxybenzylidene)-1-benzofuran-3(2H)-one 
• 487-24-1 pratol 
• 485-72-3 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on 
• 13351-10-5 2',4'-dihydroxy-4-methoxychalcone 
• 81674-91-1 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one 
• 108837-20-3 7-hydroxy-2-(4'-methoxyphenyl)chroman-4-one 

Relevant articles and documents

Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives

A series of 7-prenyloxy-2, 3-dihydroflavanone derivatives were synthesized and screened for their antidepressant-like activity. Among them, it was observed that compounds 5j and 5k were found to be the most antidepressant-like activity. In addition, it was found that compounds 5j and 5k significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus, and cortex. Compounds 5j and 5k also significantly increased the contents of 5-HIAA in the hippocampus and cortex, shut down 5-HT metabolism compared with mice treated with stress vehicle. These results suggested that compounds 5j and 5k displayed potent antidepressant-like properties that were mediated via neurochemical systems.

Scope and Applications of 2,3-Oxidative Aryl Rearrangements for the Synthesis of Isoflavone Natural Products

The reaction of flavanones with hypervalent iodine reagents was investigated with a view to the synthesis of naturally occurring isoflavones. In contrast to several previous reports in the literature, we did not observe the formation of any benzofurans via a ring contraction pathway, but could isolate only isoflavones, resulting from an oxidative 2,3-aryl rearrangement, and flavones, resulting from an oxidation of the flavanones. Although the 2,3-oxidative rearrangement allows a synthetically useful approach toward some isoflavone natural products due to the convenient accessibility of the required starting materials, the overall synthetic utility and generality of the reaction appear to be more limited than previous literature reports suggest.

Synthesis and biological evaluation of new flavonoid fatty acid esters with anti-adipogenic and enhancing glucose consumption activities

Oleoyl Formononetin (OF) has good weight loss activity and hypolipidemic activity, could improve insulin sensitivity and suppress adipogenesis. To acquire better biological activities, three series of flavonoid fatty acid esters were designed and synthesized by optimizing the structure of OF. Their bioactivities were assayed in vitro. Some of these novel compounds could effectively inhibit preadipocyte proliferation and adipogenesis. Moreover, they could enhance glucose consumption in adipocytes notably.