1097-51-4Relevant articles and documents
-
Yang,Finnegan
, p. 5845,5847 (1958)
-
-
Julian et al.
, p. 367,369 (1950)
-
Preparation method of betamethasone intermediate
-
Paragraph 0072; 0075, (2017/02/24)
The invention relates to a preparation method of a steroid drug intermediate, and concretely relates to a preparation method of a betamethasone intermediate which is 16beta-methyl-17alpha-hydroxypregna-4,9-diene-3,20-dione. The method comprises the following steps: carrying out a cyanidation reaction on 9alpha-hydroxy-4-ene-pregna-3,17-dione, carrying out a ketal protection reaction, carrying out a double elimination reaction, carrying out an epoxy reaction, and carrying out a Grignard addition hydrolysis reaction to prepare the target product. The method is a brand preparation technology for producing the betamethasone intermediate, and has the characteristics of cheap and easily available initial raw material, simple operations of all above reactions, high yield, suitableness for industrial massive production, and realization of the yield and the quality reaching satisfactory levels.
STEROID TRANSFORMATIONS. 187. MICROBIAL CONVERSION OF 3β-HYDROXY-5α-H-PREGNANES TO THEIR Δ4-3-KETO-9α-HYDROXY DERIVATIVES
Voishvillo, N. E.,Turuta, A. M.,Kamernitskii, A. V.,Dzhlantiashvili, N. D.,Dacheva-Spasova, V. K.
, p. 177 - 182 (2007/10/02)
-