1097189-03-1

Basic information

• Product Name: 2-chloro-1-(2-methoxyphenoxy)-4-nitrobenzene
• Synonyms: 2-chloro-1-(2-methoxyphenoxy)-4-nitrobenzene
• CAS NO: 1097189-03-1
• Molecular Weight: 279.68
• Mol File: 1097189-03-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-1-(2-methoxyphenoxy)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-1-(2-methoxyphenoxy)-4-nitrobenzene(1097189-03-1)
• EPA Substance Registry System: 2-chloro-1-(2-methoxyphenoxy)-4-nitrobenzene(1097189-03-1)

Safety Data

• Hazardous Substances Data: 1097189-03-1(Hazardous Substances Data)

Upstream product

• 99-54-7 3,4-dichloronitrobenzene 
• 90-05-1 2-methoxy-phenol 
• 350-30-1 3-chloro-4-fluoronitrobenzene 

Downstream Products

• 87294-24-4 3-chloro-4-(2-methoxyphenoxy)aniline 

Relevant articles and documents

Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative 2, and the veterinary anthelmintic closantel (3) led to the discovery of compound 10 a as a potent SPAK inhibitor with reduced toxicity. Compound 10 a decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs.

The application of stop-flow microwave technology to scaling-out S NAr reactions using a soluble organic base

A model SNAr reaction which gives a range of substituted diaryl ethers has been re-developed to function with the soluble organic base DBU in the place of insoluble potassium carbonate. Manufacture of these diaryl ethers has then been achieved by scaling-out in an automated stop-flow microwave reactor to give productivities of >0.5 kg per day. Analogous reaction partners have also been scaled up in this reactor to extend the scope of the study. Brief comparison in a scale-up batch microwave reactor is also made. Lastly, continuous 24 h processing is reported in this small microwave stop-flow reactor, which requires no manual intervention once started.