1097732-14-3Relevant articles and documents
A simple base-mediated halogenation of acidic sp2 C-H bonds under noncryogenic conditions
Do, Hien-Quang,Daugulis, Olafs
, p. 421 - 423 (2009)
(Chemical Equation Presented) A new method has been developed for in situ halogenation of acidic sp2 carbon-hydrogen bonds in heterocycles and electron-deficient arenes. Either selective monohalogenation or one-step exhaustive polyhalogenation is possible for substrates possessing several C-H bonds that are flanked by electron-withdrawing groups. For the most acidic arenes, such as pentafluorobenzene, K3PO4 base can be employed instead of BuLi for metalation/halogenation sequences.