109800-02-4Relevant articles and documents
Nitro-imidazoles in ferrocenyl alkylation reaction. Synthesis, enantiomeric resolution and in vitro and in vivo bioeffects
Snegur, Lubov V.,Lyapunova, Maria V.,Verina, Daria D.,Kachala, Vadim V.,Korlyukov, Alexander A.,Ilyin, Mikhail M.,Davankov, Vadim A.,Ostrovskaya, Larissa A.,Bluchterova, Natalia V.,Fomina, Margarita M.,Malkov, Victor S.,Nevskaya, Kseniya V.,Pershina, Alexandra G.,Simenel, Alexander A.
, p. 10 - 20 (2018)
Ferrocenylalkyl nitro-imidazoles (4a-h, 5a-h) were prepared via the regiospecific reaction of the α-(hydroxy)alkyl ferrocenes, FcCHR (OH) (1a–h; Fc = ferrocenyl; R = H, Me, Et, Pr, i-Pr, Ph, ortho-Cl-Ph, ortho-I-Ph), with nitro-imidazoles in aqueous organic medium (H2O-CH2Cl2) at room temperature in the presence of HBF4, within several minutes in good yields. X-ray structural data for racemic (R,S)-1-N-(benzyl ferrocenyl)-2-methyl-4-nitroimidazole (5f) were determined. The resulting enantiomers were resolved into enantiomers by analytical HPLC on modified amylose or cellulose chiral stationary phases. The viabilities of 4b, 4d, 5b, 5c in vitro, and in experiments in vivo antitumor effects of 1-N-ferrocenylethyl-4-nitroimidazole (4b) against murine solid tumor system Ca755 carcinoma were evaluated.
Palladium-catalyzed intramolecular asymmetric C-H functionalization/ cyclization reaction of metallocenes: An efficient approach toward the synthesis of planar chiral metallocene compounds
Deng, Ruixian,Huang, Yunze,Ma, Xinna,Li, Gencheng,Zhu, Rui,Wang, Bin,Kang, Yan-Biao,Gu, Zhenhua
supporting information, p. 4472 - 4475 (2014/04/17)
A palladium-catalyzed asymmetric synthesis of planar chiral metallocene compounds is reported. The reaction stereoselectively functionalized one of the ortho C-H bonds of Cp rings by intramolecular cyclization to form indenone derivatives in high yields w
