109838-79-1Relevant articles and documents
Preparation of 4- and 6-desphenyl analogues of (-)-clausenamide and alternative synthesis of (+)-epi-clausenamide
Xue, Jian Jun,Zhou, Yu Mei,Yu, Xiao Ming
, p. 1261 - 1264 (2012/01/06)
4- and 6-desphenyl analogues of (-)-clausenamide, 6 and 7, were prepared in optical active form from commercially available d-pyroglutamic acid and the known racemic pyrrolidinone 13, respectively. In order to confirm the absolute stereochemistry of (+)-
4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β- hydroxysteroid dehydrogenase II. Part 1: Synthetic approach
Cook, James H.,Barzya, Jeremy,Brennan, Catherine,Lowe, Derek,Wang, Yamin,Redman, Anikó,Scott, William J.,Wood, Jill E.
, p. 1525 - 1528 (2007/10/03)
17β-Hydroxysteroid dehydrogenase II (17β-HSD II) antagonists may provide an important way into preventing the onset of osteoporosis. The discovery of 4,5-disubstituted cis-pyrrolidinones as 17β-HSD II inhibitors led to the development of an efficient intr