1098619-73-8

Basic information

• Product Name: Methyl 2,6-dichloro-4-iodobenzoate
• Synonyms: Methyl 2,6-dichloro-4-iodobenzoate;2,6-dichloro-4-iodoBenzoic acid methyl ester
• CAS NO: 1098619-73-8
• Molecular Formula: C8H5Cl2IO2
• Molecular Weight: 330.93457
• Mol File: 1098619-73-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.909
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 2,6-dichloro-4-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,6-dichloro-4-iodobenzoate(1098619-73-8)
• EPA Substance Registry System: Methyl 2,6-dichloro-4-iodobenzoate(1098619-73-8)

Safety Data

• Hazardous Substances Data: 1098619-73-8(Hazardous Substances Data)

Usage

General Description

Methyl 2,6-dichloro-4-iodobenzoate is a chemical compound that belongs to the class of organic compounds known as benzoic acids and derivatives. It is a derivative of benzoic acid with chloro and iodo substitutions at the 2,6 positions. Methyl 2,6-dichloro-4-iodobenzoate has potential use as a pharmaceutical intermediate or as a building block in organic synthesis. It is classified as a hazardous substance and should be handled with care due to its potential health and environmental hazards.

Upstream product

• 155891-93-3 (3,5-Dichloro-4-hydroxy-phenyl)-carbamic acid tert-butyl ester 
• 5930-28-9 4-amino-2,6-dichlorophenol 
• 1098619-84-1 trifluoro-methanesulfonic acid 4-tert-butoxycarbonylamino-2,6-dichloro-phenyl ester 
• 22509-50-8 2,6-dichloro-4-nitrobenzoic acid 
• 7149-69-1 1,3-dichloro-2-methyl-5-nitrobenzene 
• 232275-50-2 methyl 2,6-dichloro-4-nitrobenzoate 
• 99-99-0 1-methyl-4-nitrobenzene 
• 409127-35-1 4-tert-butoxycarbonylamino-2,6-dichloro-benzoic acid methyl ester 
• 232275-49-9 methyl 4-amino-2,6-dichlorobenzoate 

Downstream Products

• 1258298-20-2 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-formylbenzamide 
• 1258298-19-9 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-vinylbenzamide 
• 1258298-18-8 N-(2-bromopyridin-4-yl)-2,6-dichloro-4-vinylbenzamide 
• 1258293-59-2 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(hydroxymethyl)benzamide 
• 1258298-17-7 N-(2-bromopyridin-4-yl)-2,6-dichloro-4-iodobenzamide 
• 1258295-54-3 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(methylsulfonamido)benzamide 
• 1258295-53-2 4-acetamido-2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1258295-55-4 2,6-dichloro-4-(cyclopropanecarboxamido)-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1258295-50-9 4-amino-2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide 
• 1438897-32-5 tert-butyl 4-(4-(2-bromopyridin-4-ylcarbamoyl)-3,5-dichlorophenyl)-1H-pyrazole-1-carboxylate 
• 1438897-31-4 N-(2-bromopyridin-4-yl)-2,6-dichloro-4-(1H-pyrazol-4-yl)benzamide 
• 1258295-31-6 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(1H-pyrazol-4-yl)benzamide 
• 1438897-30-3 N-(2-bromopyridin-4-yl)-2,6-dichloro-4-ethynylbenzamide 

Relevant articles and documents

A convenient synthesis of a lymphocyte function-associated antigen-1 (LFA-1) antagonist of 'Compound 4'

The lymphocyte function-associated antigen-1 (LFA-1) antagonist of 'Compound 4' was synthesised by a convenient route using cheap, commercially available starting materials and catalysts under mild reaction conditions and by easily handled reactions. The total yield in the preparation of 'Compound 4' was more than 38% via Sonogashira coupling of an iodide and an alkyne, reduction of the alkyne catalysed by Raney nickel and later steps involving hydrolysis of an ester, condensation of an acid and an amine and a final hydrolysis of an ester.

Preparation of fluorous Yamaguchi reagents and evaluation of their reactivity in esterification

Fluorous Yamaguchi (FY) reagents bearing a perfluoroalkyl chain were prepared and employed in esterification reactions; the yields were similar to those obtained with the traditional Yamaguchi (TY) reagent. Fluorous benzoic acids derived from the FY reagents were separated easily after the reaction. GC analysis revealed that the initial rates of reaction with the FY reagents were higher than those with the TY reagent. The acidities of benzoic acids produced from the FY and TY reagents were predicted by DFT to be similar (1.20 and 0.96, respectively).

PYRIDINE COMPOUNDS AND USES THEREOF

The present invention is directed to pyridine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psych