1099449-04-3Relevant articles and documents
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun n-terminal kinase
De, Surya K.,Stebbins, John L.,Chen, Li-Hsing,Riel-Mehan, Megan,Machleidt, Thomas,Dahl, Russell,Yuan, Hongbin,Emdadi, Aras,Barile, Elisa,Chen, Vida,Murphy, Ria,Pellecchia, Maurizio
experimental part, p. 1943 - 1952 (2009/12/30)
We report comprehensive structure-activity relationship studies on a novel series of c-Jun N-terminal kinase (JNK) inhibitors. The compounds are substrate competitive inhibitors that bind to the docking site of the kinase. The reported medicinal chemistry
