1100569-50-3

Basic information

• Product Name: C₁₄H₁₅NO₂
• CAS NO: 1100569-50-3
• Molecular Weight: 229.279
• Mol File: 1100569-50-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₅NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₅NO₂(1100569-50-3)
• EPA Substance Registry System: C₁₄H₁₅NO₂(1100569-50-3)

Safety Data

• Hazardous Substances Data: 1100569-50-3(Hazardous Substances Data)

Upstream product

• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 10604-60-1 (1-iodoethyl)benzene 

Downstream Products

• 1155519-30-4 C₁₃H₁₃NO₂ 

Relevant articles and documents

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death pathway resulting in morphology reminiscent of passive non-regulated necrosis. Several diverse structure classes of necroptosis inhibitors have been reported to date, including a series of [1,2,3]thiadiazole benzylamide derivatives. However, initial evaluation of mouse liver microsome stability indicated that this series of compounds was rapidly degraded. A structure-activity relationship (SAR) study of the [1,2,3]thiadiazole benzylamide series revealed that increased mouse liver microsome stability and increased necroptosis inhibitory activity could be accomplished by replacement of the 4-cyclopropyl-[1,2,3]thiadiazole with a 5-cyano-1-methylpyrrole. In addition, the SAR and the cellular activity profiles, utilizing different cell types and necroptosis-inducing stimuli, of representative [1,2,3]thiadiazole and pyrrole derivatives were very similar suggesting that the two compound series inhibit necroptosis in the same manner.