110119-84-1

Basic information

• Product Name: DONEPEZIL HYDROCHLORIDE
• Synonyms: AKOS 226-31;E-2020;DONEPEZIL HCL;ARICEPT;DonepezilHcl120011-70-3/;DONEPEZIL (DONEPEZIL HYDROCHLORIDE);2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one hydrochloride;Donepezil hydrochloride
• CAS NO: 110119-84-1
• Molecular Formula: C24H30ClNO3
• Molecular Weight: 415.95
• EINECS: 1312995-182-4
• Product Categories: API
• Mol File: 110119-84-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 527.9oC at 760 mmHg
• Flash Point: 273.1oC
• Appearance: /
• Density: 1.141 g/cm3
• Vapor Pressure: 3.11E-11mmHg at 25°C
• CAS DataBase Reference: DONEPEZIL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DONEPEZIL HYDROCHLORIDE(110119-84-1)
• EPA Substance Registry System: DONEPEZIL HYDROCHLORIDE(110119-84-1)

Safety Data

• Hazardous Substances Data: 110119-84-1(Hazardous Substances Data)

Usage

Description

Donepezil hydrochloride, marketed under the trade name Aricept, is a piperidine-type reversible cholinesterase (ChE) inhibitor. It is chemically known as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1Hinden-1-one hydrochloride, with an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. This white crystalline powder is freely soluble in chloroform, soluble in water and glacial acetic acid, slightly soluble in ethanol and acetonitrile, and practically insoluble in ethyl acetate and n-hexane. Donepezil hydrochloride can bind and reversibly inactivate cholinesterases, thereby inhibiting the hydrolysis of acetylcholine and increasing its concentration at cholinergic synapses.

Uses

Used in Pharmaceutical Industry:
Donepezil hydrochloride is used as a therapeutic agent for the treatment of symptoms associated with mild-to-severe Alzheimer's disease. By increasing the concentration of acetylcholine at cholinergic synapses, it helps improve cognitive function and memory in patients. However,

References

1. http://www.rxlist.com/aricept-drug.htm 2. http://www.medbroadcast.com/drug/getdrug/donepezil-hydrochloride 3. http://www.pdr.net/drug-summary/Aricept-donepezil-hydrochloride-138 4. https://en.wikipedia.org/wiki/Donepezil 5. https://www.drugs.com/cdi/donepezil.html

InChI:InChI=1/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

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New gradient high-performance liquid chromatography method for determination of DONEPEZIL HYDROCHLORIDE (cas 110119-84-1) assay and impurities content in oral pharmaceutical formulation08/16/2019

A new gradient HPLC method has been developed and validated for the determination of both assay and related substances of donepezil hydrochloride in oral pharmaceutical formulation. Different kinds of columns and gradient elution programs were tested in order to achieve satisfactory separation b...detailed

A new HPLC method to determine DONEPEZIL HYDROCHLORIDE (cas 110119-84-1) in tablets08/15/2019

A HPLC stability-indicating assay for Donepezil hydrochloride in tablets was developed and validated. Donepezil hydrochloride is a reversible inhibitor of acetylcholinesterase, indicated for the treatment of mild to moderate dementia of the Alzheimer's type. The HPLC method was performed wi...detailed

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Tip-loaded dissolving microneedles for transdermal delivery of DONEPEZIL HYDROCHLORIDE (cas 110119-84-1) for treatment of Alzheimer’s disease08/08/2019

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