110144-24-6Relevant articles and documents
Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease
Neudorfer, Catharina,Shanab, Karem,Jurik, Andreas,Schreiber, Veronika,Neudorfer, Carolina,Vraka, Chrysoula,Schirmer, Eva,Holzer, Wolfgang,Ecker, Gerhard,Mitterhauser, Markus,Wadsak, Wolfgang,Spreitzer, Helmut
, p. 4490 - 4495 (2014)
Since high MAO-B levels are present in early stages of AD, the MAO-B system can be designated as an appropriate and prospective tracer target of molecular imaging biomarkers for the detection of early AD. According to the preceding investigations of Mishr
Synthesis and Characterization of Blocked and Ligand-Appended Hemes Derived from Atropisomeric meso-Diphenylporphyrins
Young, Richard,Chang, C. K.
, p. 898 - 909 (2007/10/02)
The synthesis of a series of sterically blocked and imidazole-appended meso-diphenyletioporphyrins is described.These hybrid porphyrins have good solubility and spectroscopic properties of β-substituted porphyrins as well as the orientation specificity of ortho-position-derivatized tetraphenylporphyrins.The effectiveness of the blocking groups is demonstrated by ferric hemin hydroxide formation in the doubly protected trans-5,15-bis-2,8,12,18-tetraethyl-3,7,13,17-tetramethylporphine, characterized by UV-visible, 1H NMR, and IR spectra and cyclic voltammetry.The advantage of the m-benzyl linkage in enforcing imidazole coordination to ferric hemes is demonstrated by 1H NMR studies on various type of imidazole-appended heme complexes.Several potential binucleating systems have also been prepared by incorporating nonheme chelating ligands to the hybrid porphyrins.
