110230-98-3 Usage
Description
Monoaspartyl chlorin e6, also known as talaporfin sodium, is a photosensitizer developed by Nippon Petrochemicals in collaboration with Light Sciences Corp. and Meiji Seika Kaisha. It is synthesized through a carbodiimide-mediated coupling of chlorin e6 with L-aspartic acid, resulting in a mixture of aspartic acid conjugates that are purified through chromatography to obtain the desired product. Talaporfin sodium is characterized by minimal cutaneous photosensitivity, activation at long wavelengths for deeper tissue penetration, and a shorter interval between intravenous administration and photoactivation.
Uses
Used in Photodynamic Therapy:
Talaporfin sodium is used as a photosensitizer in photodynamic therapy (PDT) for the treatment of various types of cancer. It has been approved in Japan for the treatment of early-stage lung cancer and is being developed for other hyperproliferative diseases, such as liver metastases arising from colorectal cancer, wet age-related macular degeneration, and atherosclerosis.
Used in Cancer Treatment:
In the clinical study of patients with early lung cancer, talaporfin sodium demonstrated a complete response in approximately 86% of the lesions when administered at 40 mg/m2 followed by laser irradiation at 100 J/cm2, 4-6 hours later. The activated photosensitizer reacts with endogenous oxygen to generate singlet oxygen, leading to apoptosis and vascular ischemia of the targeted tissue.
Used in Light-Emitting Diode (LED) Activation:
A clinical study involving a variety of refractory solid tumors demonstrated that intratumoral delivery of light-emitting diodes was effective when used with talaporfin sodium, resulting in a 33% overall response rate with no cutaneous phototoxicity.
Brand Name: Laserphyrin
Originator
Nippon Petrochem. (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 110230-98-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,2,3 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 110230-98:
(8*1)+(7*1)+(6*0)+(5*2)+(4*3)+(3*0)+(2*9)+(1*8)=63
63 % 10 = 3
So 110230-98-3 is a valid CAS Registry Number.
InChI:InChI=1/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39-40H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/b24-12-,25-13-,26-12-,27-14-,28-13-,29-14-,35-23-,36-23-/t18-,22-,30-/m0/s1
