110281-33-9

Basic information

• Product Name: Methanone, (4-hydroxy-3-methoxyphenyl)-2-thiazolyl-
• CAS NO: 110281-33-9
• Molecular Formula: C11H9NO3S
• Molecular Weight: 235.263
• Mol File: 110281-33-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Methanone, (4-hydroxy-3-methoxyphenyl)-2-thiazolyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-hydroxy-3-methoxyphenyl)-2-thiazolyl-(110281-33-9)
• EPA Substance Registry System: Methanone, (4-hydroxy-3-methoxyphenyl)-2-thiazolyl-(110281-33-9)

Safety Data

• Hazardous Substances Data: 110281-33-9(Hazardous Substances Data)

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 40610-14-8 2-lithiothiazole 
• 121-33-5 vanillin 

Relevant articles and documents

Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives

The invention concerns a thiazole of the formula I, STR1 wherein Q1 is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents, or Ar is an optionally substituted 6-membered heterocyclene moiety continuing up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl or substituted (1-4C)alkyl or R2 is optionally substituted benzoyl; and Q2 is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I and pharmaceutical compositions containing said thiazole.

Thiazole derivatives having a 5-lipoxygenase-inhibiting activity

The invention concerns a thiazole of the formula I, wherein Ar1 is optionally substituted aryl of up to 10 carbon atoms;, A is a direct link to X, or is (1-6C)alkylene, (3-6C)alkenylene, (3--6C)alkynylene or cyclo(3-6C)alkylene;, X is oxy, thio, sulphinyl, sulphonyl or imino;, Ar2 is optionally substituted phenylene,or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;, R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;, R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, substituted (1-4C)alkyl or (2-6C)alkanoyl;, Q is optionally substituted thiazolyl;, or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said thiazole.

Thiazole and Imidazole Metabolites from the Ascidian Aplydium pliciferum

Two thiazole- and one imidazole-containing metabolites have been isolated from the Australian ascidian Aplydium pliciferum.Their structures were established by spectral methods and synthesis.