11034-93-8

Basic information

• Product Name: GB4
• Synonyms: Ceramide,1-O-[O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1-)3)-O-α-D-galactopyranosyl-(1-)4)-O-β-D-galactopyranosyl-(1-)4)-β-D-glucopyranosyl]-;CytolipinK;GangliosideGL4;globosidefromhumanerythrocytes;GlobosideGL4;GlobosideI;Globosidicacid;GBOSE4CER
• CAS NO: 11034-93-8
• Molecular Formula: C56H102N2O23
• Molecular Weight: 1171.4087
• Mol File: 11034-93-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1281.8 °C at 760 mmHg
• Flash Point: 729 °C
• Appearance: /
• Density: 1.32 g/cm³
• Refractive Index: 1.579
• Storage Temp.: −20°C
• CAS DataBase Reference: GB4(CAS DataBase Reference)
• NIST Chemistry Reference: GB4(11034-93-8)
• EPA Substance Registry System: GB4(11034-93-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 11034-93-8(Hazardous Substances Data)

Usage

Description

GB4, also known as globotetraosylceramide, is a bioactive neutral glycosphingolipid that serves as the major glycolipid in human erythrocytes. It acts as a receptor for various toxins and viruses and plays a role in dental enamel formation and neurocutaneous conditions. GB4 is a white powder in its chemical form.

Uses

Used in Medical Research:
GB4 is used as a receptor for Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19, making it an important target for medical research on the development of treatments and vaccines for these pathogens.
Used in Dental Research:
GB4 is used as a stimulator of enamel deposition protein expression in dental epithelial cells, including ameloblastin, amelogenin, and enamelin. It activates the ERK and p38 MAPK signaling pathways, which are crucial for tooth development and regeneration.
Used in Neurocutaneous Condition Studies:
GB4 is used as a biomarker for salt and pepper syndrome, a neurocutaneous condition characterized by intellectual disability and hyperand hypo-pigmented skin. Elevated levels of GB4 in fibroblasts from patients with this condition can help in understanding the pathophysiology and developing potential therapeutic strategies.
Used in Biochemistry and Lipid Research:
GB4 (porcine RBC) is used as a source of globotetraosylceramides with variable fatty acyl chain lengths isolated from porcine red blood cells. This provides researchers with a valuable tool for studying the structure, function, and interactions of glycosphingolipids in various biological processes.

InChI:InChI=1/C56H102N2O23/c1-4-6-8-10-12-14-15-16-17-19-20-22-24-26-35(64)34(58-40(65)27-25-23-21-18-13-11-9-7-5-2)32-74-54-47(71)45(69)50(38(30-61)77-54)79-55-48(72)46(70)51(39(31-62)78-55)80-56-49(73)52(43(67)37(29-60)76-56)81-53-41(57-33(3)63)44(68)42(66)36(28-59)75-53/h24,26,34-39,41-56,59-62,64,66-73H,4-23,25,27-32H2,1-3H3,(H,57,63)(H,58,65)/b26-24+/t34-,35+,36+,37+,38+,39+,41+,42-,43-,44+,45+,46+,47?,48+,49+,50+,51-,52-,53-,54+,55-,56+/m0/s1