110360-09-3

Basic information

• Product Name: 5-O-TOLYL-FURAN-2-CARBALDEHYDE
• Synonyms: AKOS BAR-0558;5-O-TOLYL-FURAN-2-CARBALDEHYDE;5-(2-METHYLPHENYL)-2-FURALDEHYDE;2-FURANCARBOXALDEHYDE, 5-(2-METHYLPHENYL)-;5-(2-METHYLPHENYL)-2-FURANCARBOXALDEHYDE
• CAS NO: 110360-09-3
• Molecular Formula: C₁₂H₁₀O₂
• Molecular Weight: 186.21
• Mol File: 110360-09-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-O-TOLYL-FURAN-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-O-TOLYL-FURAN-2-CARBALDEHYDE(110360-09-3)
• EPA Substance Registry System: 5-O-TOLYL-FURAN-2-CARBALDEHYDE(110360-09-3)

Safety Data

• Hazardous Substances Data: 110360-09-3(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 615-37-2 ortho-methylphenyl iodide 
• 95-53-4 o-toluidine 
• 1210824-94-4 C₇H₈N₂*ClH 
• 2689-65-8 5-iodofuran-2-carbaldehyde 
• 16419-60-6 2-Methylphenylboronic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 2028-34-4 o-toluene-diazonium chloride 

Downstream Products

• 1138035-93-4 4-bromo-5-(2-methylphenyl)furan-2-carbaldehyde 
• 80174-04-5 5-(o-tolyl)-2-furoic acid 
• 1192599-28-2 2-((5-o-tolylfuran-2-yl)methylene)hydrazinecarboximidamide hydrochloride 
• 639517-74-1 2-benzoylamino-3-(5-o-tolyl-furan-2-yl)-acrylic acid methyl ester 

Relevant articles and documents

5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors

Two series of 5-aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors. Among the compounds studied, 5g was found to have the best PTP1B inhibitory potency (IC50 = 2.66 ± 0.16 μM) and the best cell division cycle 25 homolog B (CDC25B) inhibitory potency (IC50 = 0.25 ± 0.02 μM). Enzymatic data together with molecular modeling results demonstrated that the introduction of a sec-butyl group at the 2-position of the carboxyl group remarkably improved the PTP1B inhibitory activity.

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Access to Densely Functionalized Chalcone Derivatives with a 2-Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan-Yne Cyclization of N -(2-Furanylmethyl) Alkynamides under Air

A protocol for synthesis of chalcone derivatives with a 2-pyridone subunit from N-(2-furanylmethyl) alkynamides is reported. This synthesis involves Pd/Cu-catalyzed oxidative furan-yne cyclization at room temperature in air and may proceed via nucleopalladation of the alkyne to form a vinylpalladium intermediate, with a furan ring acting as the nucleophile.