110407-68-6

Basic information

• Product Name: Propanoic acid, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (2R)-
• CAS NO: 110407-68-6
• Molecular Formula: C19H24O3Si
• Molecular Weight: 328.483
• Mol File: 110407-68-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (2R)-(110407-68-6)
• EPA Substance Registry System: Propanoic acid, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (2R)-(110407-68-6)

Safety Data

• Hazardous Substances Data: 110407-68-6(Hazardous Substances Data)

Upstream product

• 90246-33-6 (R)-ethyl 2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>propanoate 
• 10326-41-7 D-Lactic acid 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 561038-05-9 (R)-2-(tert-butyldiphenylsilanyloxy)propionic acid methyl ester 

Downstream Products

• 90246-34-7 S-(2-pyridinyl) 2(R)-((tert-butyldiphenylsilyl)oxy)propanthioate 
• 1356477-65-0 (2R)-2-t-butyldiphenylsilyloxyhex-4-yn-3-one 
• 1239453-30-5 C₂₆H₃₀O₃Si 
• 1239453-31-6 C₂₈H₃₂O₅Si 
• 1239453-33-8 C₂₉H₃₄O₅Si 
• 90246-49-4 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<6-oxo-2(R),5-dimethyl-7(R)-(tert-butyldiphenylsiloxy)-4(E)-octenylidene>octahydroindolizidine 
• 182052-99-9 (E)-(2R,3R,7R)-9,9-Dibromo-2-(tert-butyl-diphenyl-silanyloxy)-4,7-dimethyl-nona-4,8-dien-3-ol 
• 90246-35-8 (R)-2-((tert-butyldiphenylsilyl)oxy)-4-(triphenylphosphoranylidene)-3-pentanone 
• 137895-74-0 (3R,5E,8R)-8-tert-butyldiphenylsiloxy-1,1-dibromo-3,6-dimethyl-7-oxo-1,5-nonadiene 
• 857478-53-6 (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid pentafluorophenyl ester 
• 857478-37-6 (2R,4S)-1-((S)-2-{(S)-2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-diphenyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-butyrylamino}-3-phenyl-propionyl)-4-methyl-pyrrolidine-2-carboxylic acid benzyl ester 
• 857478-39-8 (2S,5S,8S,11S,13aR)-5-Benzyl-11-[(R)-7-(tert-butyl-diphenyl-silanyloxy)-6-oxo-octyl]-8-ethyl-2,8-dimethyl-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone 
• 857478-17-2 (2S,9R)-9-(tert-butyldiphenylsiloxy)-8-oxo-2-(tert-butoxycarbonyl)-amino-4-decenoic acid benzyl ester 

Relevant articles and documents

SYNTHESIS AND IN VITRO ACTIVITY OF D-LACTIC ACID OLIGOMERS

This invention describes the synthesis and pharmacologic activity of n=2, n=3, n=4, n=5, and n=6 D-lactic acid oligomers. D-lactic acid dimer has pharmacologic activity and sequesters L-lactate, and the other D-lactic acid oligomers have no activity in vitro, but may have pharmacologic activity in vivo as prodrugs of D-lactic acid dimer.

New insights into poly(lactic- co -glycolic acid) microstructure: Using repeating sequence copolymers to decipher complex NMR and thermal behavior

Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range Mn = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the 1H and 13C NMR spectra, the diastereotopic methylene resonances in the 1H NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.

Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases

(Chemical Equation Presented) The total synthesis of FR235222, a potent immunosuppressant with in vivo activities, has been achieved. The key steps include assembling its (2S,9R)-2-amino-9-hydroxy-8-oxodecanoic acid residue via an olefin cross-metathesis of a methyl (R)-lactate-derived homoallyl ketone with protected allyl amino acid and constructing its trans-(2R,4S)-4-methylproline unit from protected (R)-pyroglutamic acid in seven steps.