11042-64-1 Usage
Description
Gamma-Oryzanol is a lipid fraction derived from rice-bran oil, consisting of a mixture of ferulic acid esters and plant sterols. It is structurally similar to cholesterol and comprises compounds such as campesterol, stigmasterol, beta sitosterol, cycloartanol, and cycloartenol. Gamma-Oryzanol exhibits a wide range of biological activities, including anticarcinogenic, anti-inflammatory, antihyperlipidemic, and neuroprotective properties, primarily due to its high antioxidant capacity.
Uses
Used in Pharmaceutical Applications:
Gamma-Oryzanol is used as a pharmaceutical material for treating menopausal symptoms, mild anxiety, stomach upset, and high cholesterol.
Used in Sports Supplements:
Gamma-Oryzanol is used as a sports supplement for reducing cholesterol and enhancing athletic performance.
Used in Food Industry:
Gamma-Oryzanol is used as a food additive to improve the nutritional value and provide health benefits.
Used in Cosmetics:
Gamma-Oryzanol is used in creams and sunscreens as a skin age resistor and for its ultraviolet absorbing effect.
Used in Rice-Bran Oil:
Gamma-Oryzanol is found in rice-bran oil, which is commercially available for use in salad oils and frying, contributing to its health benefits.
Chemical Properties:
Gamma-Oryzanol is a white to off-white solid.
Preparation
Extraction of gamma oryzanol from processes oil. Gamma oryzanol can be extracted by liquid-liquid extraction method by using organic solvent or by using supercritical extraction method. The following procedure was followed to extract gamma oryzanol from the oil.Rice Bran Oil (1 kg)→NaOH and water was added→Stirred and stored for one day at room temperature→Acidified to pH 4 using H2SO4→Heated to 80°C→50g NaCl was added→Oily layer was obtained→ Methanol was added→ Mixture was cooled to 0°C for 2 hrs.→ Waxy component precipitated→ Solution of 5g H2SO4 in 300 ml methanol→ Stored for one day→ Stirred at 40°C to remove/evaporate methanol→ To 100g residue 100g n-hexane was added→ Solvent Distillation→ Treatment of 100 ml methanol was given→ Residue was extracted 3 times with 50ml 0.5N→ methanolicNaOH→ Neutralised with methanolic acetic acid to pH 6.8-7→ Stored to precipitate gamma oryzanol.The yield of gamma oryzanol was found to be 2.2%
Side effects
Gamma oryzanol has no side effects for horses, dogs or humans. Toxicity studies on animals demonstrate that gamma oryzanol is a very safe compound. No significant side-effects have been reported in human trials at the above noted recommended dosage.Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.
Safety Profile
A poison by skin contact. Moderately toxic by intravenous route. Low toxicity by ingestion. Experimental reproductive effects. When heated to decompositionit emits acrid smoke and irritating vapors.
Dosage
A typical dosage of gamma oryzanol is 500 mg daily.
Check Digit Verification of cas no
The CAS Registry Mumber 11042-64-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,4 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 11042-64:
(7*1)+(6*1)+(5*0)+(4*4)+(3*2)+(2*6)+(1*4)=51
51 % 10 = 1
So 11042-64-1 is a valid CAS Registry Number.
InChI:InChI=1/C40H58O4/c1-26(2)10-9-11-27(3)29-18-20-38(7)33-16-15-32-36(4,5)34(19-21-39(32)25-40(33,39)23-22-37(29,38)6)44-35(42)17-13-28-12-14-30(41)31(24-28)43-8/h10,12-14,17,24,27,29,32-34,41H,9,11,15-16,18-23,25H2,1-8H3/b17-13+/t27?,29-,32?,33?,34+,37-,38+,39-,40+/m1/s1
