11046-99-4 Usage
Uses
Different sources of media describe the Uses of 11046-99-4 differently. You can refer to the following data:
1. α-Crystallin is a lens protein that contains two homologous subunits: αA- and αB-crystallins. α-Crystallin displays chaperone-like activity and plays an important role in maintaining lens transparency. It has been noted that in diabetic conditions of rats there is a decline in the chaperone activity of α-Crystallin. Research has shown that a dietary antioxidant, curcumin, can prevent this loss of chaperone activity.
2. βL-Crystallin is one of the major lens proteins that aggregates under UV. A chaperone mixture of D-pathethine and N-acetyl carnosine has the ability to slow down the rate of photoaggregatin βL-Crystallin, and may be important in the prevention of cataract.
General Description
β-Crystallin is the most heterogeneous of the crystallin classes, with at least six different gene products, at least ten different post-translational modifications, and quaternary structure variants from dimers to octamers. However, all sequences are highly conserved through evolution.
Biochem/physiol Actions
α-Crystallin is a small heat-shock protein that has chaperone-like activity, preventing protein aggregation in vitro. Point mutations in α-crystallin genes are believed to be responsible for hereditary cataract development.
Check Digit Verification of cas no
The CAS Registry Mumber 11046-99-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,4 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 11046-99:
(7*1)+(6*1)+(5*0)+(4*4)+(3*6)+(2*9)+(1*9)=74
74 % 10 = 4
So 11046-99-4 is a valid CAS Registry Number.