11052-72-5 Usage
Description
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is a macrolide antibiotic that acts as a specific inhibitor of mitochondrial F1F0-ATPase. It is toxic to other organisms and can induce cell death by inhibiting ATP synthesis, leading to a switch in the death mode from apoptosis to necrosis.
Uses
Used in Pharmaceutical Industry:
Oligomycin C is used as an ATP synthetase and RVD inhibitor for its ability to make cells more susceptible to cell death and induce a switch in the death mode from apoptosis to necrosis. This property makes it a potential candidate for the development of drugs targeting specific cellular processes and pathways.
Used in Research Applications:
Oligomycin C is used as a research tool to study the role of mitochondrial F1F0-ATPase in cellular metabolism and its inhibition in various biological processes. It helps researchers understand the mechanisms of action and potential therapeutic applications in the treatment of diseases associated with mitochondrial dysfunction.
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
references
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
Check Digit Verification of cas no
The CAS Registry Mumber 11052-72-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,5 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 11052-72:
(7*1)+(6*1)+(5*0)+(4*5)+(3*2)+(2*7)+(1*2)=55
55 % 10 = 5
So 11052-72-5 is a valid CAS Registry Number.
InChI:InChI=1/C45H74O10/c1-12-35-17-15-13-14-16-26(3)39(48)30(7)41(50)32(9)43(52)33(10)42(51)31(8)40(49)27(4)18-21-38(47)53-44-29(6)36(20-19-35)54-45(34(44)11)23-22-25(2)37(55-45)24-28(5)46/h13-15,17-18,21,25-37,39-40,43-44,46,48-49,52H,12,16,19-20,22-24H2,1-11H3
