110522-84-4

Basic information

• Product Name: DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)
• Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite];DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE);IBU-4,4'-DMT-deoxycytidine cyanoethyl DIIP phosphoramidite;Cytidine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-,3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI);N4-Isobutyryl-5'-O-DMT-2'-deoxycytidine-3'-CE Phosphoramidite;5'-O-DMT-N4-Isobutyryl-2'-deoxycytidine-3'-CE Phosphoramidite;2'-Deoxy-5'-O-DMT-N4-isobutyrylcytidine 3'-CE phosphoramidite
• CAS NO: 110522-84-4
• Molecular Formula: C43H54N5O8P
• Molecular Weight: 799.901
• EINECS: 2017-001-1
• Mol File: 110522-84-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• PKA: 10.01±0.20(Predicted)
• CAS DataBase Reference: DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)(CAS DataBase Reference)
• NIST Chemistry Reference: DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)(110522-84-4)
• EPA Substance Registry System: DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)(110522-84-4)

Safety Data

• Hazardous Substances Data: 110522-84-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid powder

Upstream product

• 951-77-9 2'-Deoxycytidine 
• 110522-75-3 N⁴-isobutyryll-2'-deoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 102691-36-1 N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite 
• 100898-62-2 N-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)isobutyramide 

Relevant articles and documents

FAST OLIGONUCLEOTIDE DEPROTECTION. PHOSPHORAMIDITE CHEMISTRY FOR DNA SYNTHESIS

A new set of base protecting groups for cyanoethylphosphoramidite nucleosides has been developed which decreases the post-synthesis time requirements.The traditional purine amide protecting groups, which require 8 - 16 hours at 55 deg C for deprotection in ammonia, have been replaced with the dimethylformamidine group.Oligonucleotides made with the new reagents require only 1 hour at 55 deg C or 8 hours at room temperature for complete deprotection.Dialkylformamidine phosphoramidites exhibit enhanced resistance to depurination compared to the traditional, or even the phenoxyacetyl, phosphoramidites.