110706-50-8

Basic information

• Product Name: DIMETHY-4-FLUOROPHTHALATE
• Synonyms: DIMETHY-4-FLUOROPHTHALATE;4-fluorophthalic acid dimethyl ester;Dimethyl4-fluorophthalate;1,2-BENZENEDICARBOXYLIC ACID,4-FLUORO-,1,2-DIMETHYL ESTER
• CAS NO: 110706-50-8
• Molecular Formula: C₁₀H₉FO₄
• Molecular Weight: 212.17
• Product Categories: Benzoic acid
• Mol File: 110706-50-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 251.994 °C at 760 mmHg
• Flash Point: 103.127 °C
• Appearance: slight yellow liquid
• Density: 1.252 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: DIMETHY-4-FLUOROPHTHALATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHY-4-FLUOROPHTHALATE(110706-50-8)
• EPA Substance Registry System: DIMETHY-4-FLUOROPHTHALATE(110706-50-8)

Safety Data

• Hazardous Substances Data: 110706-50-8(Hazardous Substances Data)

Upstream product

• 1265460-40-9 3-benzyloxy-5-fluorocyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester 
• 67-56-1 methanol 
• 319-03-9 4-fluorophthalic anhydride 
• 157170-48-4 dimethyl 5-bromo-4-chloro-4-fluoro-3,4,5,6-tetrahydrophthalate 
• 99070-89-0 4-chloro-cyclohexa-1,4-diene-1,2-dicarboxylic acid dimethyl ester 
• 148541-85-9 2-fluoro-1-trimethylsilyloxy-1,3-butadiene 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 62558-08-1 4-fluoro-2-(hydroxymethyl)benzyl alcohol 
• 240400-89-9 dimethyl 4-(1H-1-pyrazolyl)phthalate 
• 146271-59-2 2,2'-(4-fluoro-1,2-phenylene)bis(2-propanol) 

Relevant articles and documents

Optimization of Orally Bioavailable PI3KδInhibitors and Identification of Vps34 as a Key Selectivity Target

Optimization of a lead series of PI3Kδinhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδover Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicological outcomes at similar exposure levels to compound 19.

BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR LIGANDS

A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1 to R8, X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of s

Synthesis of 4-substituted phthalic anhydrides

Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula STR1 The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula STR2 The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula STR3 where R1, R2, and R4 are preferably H and R3 is preferably Cl or F.