1107621-02-2

Basic information

• Product Name: ethyl 4-oxo-4-(4-phenylthiazol-2-ylamino)butanoate
• Synonyms: ethyl 4-oxo-4-(4-phenylthiazol-2-ylamino)butanoate
• CAS NO: 1107621-02-2
• Molecular Weight: 304.37
• Mol File: 1107621-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-oxo-4-(4-phenylthiazol-2-ylamino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-oxo-4-(4-phenylthiazol-2-ylamino)butanoate(1107621-02-2)
• EPA Substance Registry System: ethyl 4-oxo-4-(4-phenylthiazol-2-ylamino)butanoate(1107621-02-2)

Safety Data

• Hazardous Substances Data: 1107621-02-2(Hazardous Substances Data)

Upstream product

• 2010-06-2 2-Amino-4-phenylthiazole 
• 1070-34-4 butanedioic acid, monoethyl ester 

Relevant articles and documents

Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-Ribose) polymerase-1 inhibitors

A series of novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors were designed within 2-aminothiazole analogues (4-10) based on a constructed three-dimensional pharmacophore model. After synthesis, the inhibitory effect on PARP-1 activity and the cytoprotective action of these compounds were tested and evaluated. Among them, compounds 4-6 and 10 appeared to be potent PARP-1 inhibitors with IC50 values less than 1 μM, which had been perfectly predicted by pharmacophore model. These compounds proved to be highly potent against cell injury induced by H2O2 and oxygen-glucose deprivation (OGD) in PC12 cells. These novel 2-aminothiazole analogues are potentially applicable as neuroprotective agents for the treatment of neurological diseases.