110766-33-1

Basic information

• Product Name: 5-methyl-6-phenyl-4,5-dihydro-2H-pyridazin-3-one
• Synonyms: 5-methyl-6-phenyl-4,5-dihydro-2H-pyridazin-3-one
• CAS NO: 110766-33-1
• Molecular Weight: 188.229
• Mol File: 110766-33-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-methyl-6-phenyl-4,5-dihydro-2H-pyridazin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-6-phenyl-4,5-dihydro-2H-pyridazin-3-one(110766-33-1)
• EPA Substance Registry System: 5-methyl-6-phenyl-4,5-dihydro-2H-pyridazin-3-one(110766-33-1)

Safety Data

• Hazardous Substances Data: 110766-33-1(Hazardous Substances Data)

Upstream product

• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 51765-79-8 3-methyl-4-oxo-4-phenylbutanenitrile 
• 7315-67-5 3-methyl-4-oxo-4-phenylbutanoic acid 

Downstream Products

• 172542-41-5 4-Methyl-3-phenyl-1,4,5,6-tetrahydro-pyridazine 

Relevant articles and documents

A kind of levosimendan impurity and its preparation and detection method

The invention discloses a levosimendan impurity, and the impurity is produced in diazotization and condensation reaction in the presence of alcohol (such as ethanol), water and other nucleophiles in the synthesis process of levosimendan. The invention also provides a preparation method of the impurity, the preparation method comprises the steps of preparation of formula III compound by diazotization from 6-(4-amino phenyl)-4, 5-dihydro-5-methyl-3 (2H) - pyridazinone, and preparation of the impurity by reaction of the formula III compound and TOH. The invention also provides a detection method of the impurity and application of the impurity in the study of the quality of levosimendan pharmaceutical raw materials and preparations.

Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

A novel series of nonsteroidal heterocycles was discovered which display cell-type selective, high-affinity (nanomolar) binding to the progesterone receptors from TE85 osteosarcoma cells but > 1 μM binding affinity to the progesterone receptors from T47D and ZR75 human breast carcinpma cells.Structure-activity relationships were developed for a set of these compounds, and a representative analog 1-(3,4-dichlorobenzoyl)-3-phenyl-1,4,5,6-tetrahydropyridazine (1i, RWJ 25333) was chosen for further evaluation.RWJ 25333 stimulated the in vitro proliferation of human osteoblast-like cells but not human breast cells.