1108200-12-9

Basic information

• Product Name: (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine
• Synonyms: (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine
• CAS NO: 1108200-12-9
• Molecular Weight: 231.218
• Mol File: 1108200-12-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine(1108200-12-9)
• EPA Substance Registry System: (S)-N-acetyl-3-phenyl-1,1,1-trifluoro-2-propyl amine(1108200-12-9)

Safety Data

• Hazardous Substances Data: 1108200-12-9(Hazardous Substances Data)

Upstream product

• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 6921-34-2 benzylmagnesium chloride 
• 108-21-4 Isopropyl acetate 
• 404-20-6 (+/-)-1,1,1-trifluoro-3-phenyl-2-aminopropane 
• 158388-65-9 N-(1,1,1-trifluoro-3-phenyl-iso-propylidene)benzylamine 
• 328-61-0 N-(1,1,1-trifluoro-3-phenylpropan-2-yl)acetamide 
• 35373-60-5 3-trifluoromethyltetrahydroisoquinoline 
• 348-73-2 oxime de la trifluoro-methyl benzyl cetone 

Downstream Products

• 35373-60-5 3-trifluoromethyltetrahydroisoquinoline 
• 1639939-99-3 C₁₂H₁₄F₃NO₂ 

Relevant articles and documents

Highly efficient synthesis of chiral α-CF3 amines via Rh-catalyzed asymmetric hydrogenation

Highly enantioselective catalytic asymmetric hydrogenation of α-CF3-enamides has been achieved by employing rhodium-DuanPhos as the catalyst, which provides a readily accessible method for the synthesis of chiral trifluoromethylated amines. The reaction has a broad substrate scope; both aryl- and alkyl-substituted α-CF3-enamides worked smoothly and afford the corresponding chiral amines in high yields and excellent enantioselectivities (up to 99% ee).

Chemoenzymatic dynamic kinetic resolution of α-trifluoromethylated amines: Influence of substitutions on the reversed stereoselectivity

Enzymatic resolution of α-trifluoromethylated amines via kinetic resolution (KR), dynamic kinetic resolution (DKR) employing CALB-Pd/Al 2O3, and a one-pot sequential process of KR/DKR/KR was investigated comparatively for the first time. Although CALB-catalyzed KR of α-trifluoromethylated amines with substituents of methyl (1a), isopropyl (1c), phenyl (1d) and benzyl group (1e) can provide good stereoselectivity factors E from 31 to >200 respectively, DKR and sequential process of KR/DKR/KR possess better practical application potential because of the higher conversion (62%-84%) and the similar enantiomeric excesses (90%-99%). The enantiopreference and inversion for the α-trifluoromethylated amines displayed by CALB were observed and explained by docking modes. Namely, for 1,1,1-trifluoro-2-propylamine (1a), the product amide with R-configuration was obtained, and the enantiopreference was converted to S for the amines (1b-1e) with substituents larger than methyl group. The catalysts recycle, and scale-up experiments were demonstrated successfully. All these results indicated the high efficiency and green feature of this enzymatic process, and its application significance.