110880-55-2

Basic information

• Product Name: (SAR9,MET(O2)11)-SUBSTANCE P
• Synonyms: (SAR9,MET(O2)11)-SUBSTANCE P;RPKPQQFFSARLM(O2);H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2;ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2;[SAR9 ,MET(O2 )11 ]-SUBSTANCE P HIGHLY SPECIFIC NEUROKININ NK1 RECEPTOR 97+%;[Sar9,met(o2)11]-substancephighlyspecificneurokininnk1receptor;substance P, Sar(9)-Met(O2)(11)-;[Sar9,Met(O2)11]SP
• CAS NO: 110880-55-2
• Molecular Formula: C64H100N18O15S
• Molecular Weight: 1393.66
• Product Categories: Tachykinin receptor
• Mol File: 110880-55-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.43g/cm³
• Refractive Index: 1.656
• Storage Temp.: −20°C
• PKA: 13.31±0.20(Predicted)
• CAS DataBase Reference: (SAR9,MET(O2)11)-SUBSTANCE P(CAS DataBase Reference)
• NIST Chemistry Reference: (SAR9,MET(O2)11)-SUBSTANCE P(110880-55-2)
• EPA Substance Registry System: (SAR9,MET(O2)11)-SUBSTANCE P(110880-55-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 110880-55-2(Hazardous Substances Data)

Usage

Description

(SAR9,MET(O2)11)-SUBSTANCE P, also known as [Sar9,Met(O2)11]-Substance P, is a potent and selective NK1 tachykinin receptor agonist. It is a synthetic peptide derived from the naturally occurring neuropeptide Substance P. The NK1 tachykinin receptor, a member of the G-protein coupled receptor family, is predominantly found in neurons, brainstem, and vascular endothelial cells. This receptor plays a crucial role in various physiological processes and has been identified as a potential therapeutic target for certain conditions, including pancreatic cancer.

Uses

Used in Pharmaceutical Industry:
(SAR9,MET(O2)11)-SUBSTANCE P is used as a therapeutic agent for targeting pancreatic cancer. The NK1 tachykinin receptor, which this compound selectively activates, has been identified as a potential therapeutic target for pancreatic cancer treatment. By modulating the activity of this receptor, (SAR9,MET(O2)11)-SUBSTANCE P may help in the development of novel treatment strategies for this aggressive form of cancer.
Additionally, due to its agonistic activity on the NK1 tachykinin receptor, (SAR9,MET(O2)11)-SUBSTANCE P may also be used in research and development for other applications related to the understanding and modulation of the receptor's role in various physiological processes. This could potentially lead to the discovery of new therapeutic approaches for a range of conditions beyond pancreatic cancer.

Biochem/physiol Actions

Highly selective NK-1 receptor agonist.

InChI:InChI=1/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1