11095-43-5

Basic information

• Product Name: benzothiophene
• Synonyms: 1-benzothiophene;2,3-Benzothiophene
• CAS NO: 11095-43-5
• Molecular Formula: C8H6S
• Molecular Weight: 134.1982
• EINECS: 202-395-7
• Mol File: 11095-43-5.mol
• Article Data: 149

Chemical Properties

• Melting Point: 28-32℃
• Boiling Point: 221 °C at 760 mmHg
• Flash Point: 62 °C
• Appearance: /
• Density: 1.187 g/cm³
• Vapor Pressure: 0.163mmHg at 25°C
• Refractive Index: 1.675
• Water Solubility: insoluble
• CAS DataBase Reference: benzothiophene(CAS DataBase Reference)
• NIST Chemistry Reference: benzothiophene(11095-43-5)
• EPA Substance Registry System: benzothiophene(11095-43-5)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:
• Hazardous Substances Data: 11095-43-5(Hazardous Substances Data)

Usage

General Description

Benzothiophene is a heterocyclic compound with a fused benzene and thiophene ring structure. It is a colorless liquid with a distinct odor and is commonly used as a precursor for pharmaceuticals, agrochemicals, and dyes. Benzothiophene is also found in coal tar and is a byproduct of coal combustion. It is known to have mutagenic and carcinogenic properties, and exposure to benzothiophene is associated with potential health risks. Due to its chemical properties and potential hazards, it is important to handle and dispose of benzothiophene safely and responsibly.

InChI:InChI=1/C8H6S/c1-2-4-8-7(3-1)5-6-9-8/h1-6H

Upstream product

• 7342-82-7 3-Bromothianaphthene 
• 520-72-9 3-hydroxybenzothiophene 
• 110-01-0 thiophene 
• 108-90-7 chlorobenzene 
• 188290-36-0 thiophene 
• 16839-97-7 2-methoxythiophene 
• 462-80-6 benzyne 
• 36748-88-6 3-iodobenzo[b]thiophene 
• 15480-89-4 potassium enolate of acetophenone 
• 21300-32-3 cyclohexanone potassium enolate 
• 1645-69-8 2,2,3,3-tetrafluoro-2,3-dihydrobenzothiophene 
• 98-81-7 1-bromovinylbenzene 
• 1074-11-9 1-(1,2-dichloroethyl)benzene 
• 107-19-7 propargyl alcohol 

Downstream Products

• 63471-83-0 4-benzo[b]thiophen-3-yl-4-oxo-butyric acid 
• 74324-97-3 4-(2'-benzothienyl)-4-oxobutanoic acid 
• 501917-82-4 2-(benzo[b]thiophene-2-carbonyl)-benzoic acid 
• 17890-56-1 benzothiophene-2-methanol 
• 22720-67-8 3-(2-methylbenzoyl)benzothiophene 
• 19492-96-7 1-benzo[b]thiophen-3-yl-propan-1-one 
• 6454-03-1 benzo[b]thiophen-3-yl(phenyl)methanone 
• 39620-22-9 3-(4-methoxybenzoyl)benzothiophene 
• 107916-98-3 3-(2-nitro-phenylsulfanyl)-benzo[b]thiophene 
• 858820-12-9 benzo[b]thiophen-3-yl-diphenyl-acetic acid 
• 1128-05-8 3-acetylbenzothiophene 
• 24444-96-0 4-benzo[b]thiophen-3-yl-4-oxo-butyric acid methyl ester 
• 1196-81-2 2-ethylbenzo[b]thiophene 
• 7342-86-1 3-chloro-benzo[b]thiophene 

Relevant articles and documents

A novel synthesis of benzo[b]thiophene

We report a convenient method of preparation of benzo[b]thiophene, using 2-chlorobenzaldehyde and 2-mercaptoacetonitrile as starting materials. The process comprises two steps, neither of which has been reported previously. The reactions in this work are

Charge-Transfer Complexes of Benzo[b]thiophene with σ- And π-Electron Acceptors

The spectrophotometric properties of the charge-transfer (CT) complexes of benzo[6]thiophene with iodine at 24°C in different solvents such as cychlohexane, carbon tetrachloride, chloroform, dichloromethane, and 1,2-dichloroethane are studied. In addition the spectrophotometric and thermodynamic properties of the CT complexes of benzo[b]thiophene with tetracyanoethylene, chloranil, 2,3-dichloro-5,6-dicyano-p-benzoquinone and 7,7,8,8,-tetracyanoquinodimethane are studied. The results show that the equilibrium and the thermodynamic parameters and the wavelengths of the maximum absorption bands (λmax) of the complexes vary markedly with the solvent. The ionization potential and the donor sites of benzo[b]thiophene are also determined and discussed.

A convenient one-pot preparation of benzo[b] -tellurophenes, - selenophenes, and -thiophenes from o- bromoethynylben zenes

2-Substituted and unsubstituted benzo[b]tellurophenes (3Aa-e) were synthesized in one-pot from o-bromoethynylbenzenes (2) via three steps in good yields. Similarly, benzo[b]-selenophenes (3Ba-e) and -thiophenes (3Ca- e) were also obtained.

Synthesis and reactivities of a highly strained thiophene with two fused four-membered rings, 1,2,4,5-tetahydrodicyclobuta[b,d] thiophene

The successful synthesis of 1,2,4,5-tetrahydrodicyclobuta[b,d]thiophene (1) and its ususually enhanced reactivities because of large ring strain are described. Thus, intramolecular pinacol coupling of diketo sulflde 14, obtainable from 2-bromocyclobutanone and sodium sulfide, with a low-valent titanium reagent affords the thiolane3,4-diol 15 in 36% yield based on the bromo ketone. After conversion of 15 to the bis-methanesulfonate 16 in 66% yield, the latter was treated with potassium tert-butoxide to give 1 nearly quantitatively as a rather thermally stable, colorless, highly sublimative, nicely crystalline compound. Bromine rapidly adds to 1 to give the tetrabromide 21, revealing its olefinic character. Furthermore, 1 undergoes Diels-Alder reaction with tetracyanoethylene at room temperature to afford the adduct 22 in 83% yield. The Diels-Alder reaction with maleic anhydride at room temperature gives the adduct 23 in 87% yield in the endo-exo isomer ratio 5:1, whereas the reaction with excess maleic anhydride in refluxing benzene produces the bisadduct 24 in 84% yield with loss of sulfur. Similar behaviors of 1 toward N-phenylmaleimide were also observed. Flash vacuum pyrolysis of 1 gave benzo[b]thiophene in 16% yield but not the expected radialene 11 or its dimer, superthiophenophane. Other attempts to obtain 11 or to trap it with a dienophile were also unsuccessful.

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The role of neighbouring group participation in TTF-mediated 'radical- polar crossover' reactions: Trapping of aliphatic radicals by TTF+.

Trapping of secondary alkyl radicals with tetrathiafulvalenium tetrafluoroborate (TTF+.BF4-) leads to S-alkyltetrathiafulvalenium tetrafluoroborate salts; the solvolysis of such salts is critically dependent on the presence of appropriately sited neighbouring groups.

1,3-Cycloaddition of Benzyne to Thiophenes

Benzyne, generated from diphenyliodonium-2-carboxylate, reacts with various thiophens by addition to the sulphur and β-carbon to give, after loss of an acetylene moiety, benzothiophenes in low but reproducible yields.

Kinetics of bromine-magnesium exchange reactions in heteroaryl bromides

Competition experiments are reported which compare the relative reactivities of bromoheteroarenes toward i-PrMgCl.LiCl in THF at 0 °C

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Synthesis, crystal structure and reactivity of η2-thiophyne Ni complexes

The first synthesis and crystal structures of five-membered ring aryne complexes, Ni(dcpe)(η2-thiophyne) and Ni(dcpe)(η2-benzo[b]thiophyne), are described. The aryne fragments retain considerable aromatic character and the two coordi

AN UNUSUAL CONVERSION OF 2,2,3,3-TETRAFLUORO-2,3-DIHYDROBENZOTHIOPHENE WITH LITHIUM ALUMINUM HYDRIDE

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The preparation of (Z)-2-lithio-ortho-styryllithium via an ortho-directed lithiation

Lithiation of (Z)-2-lithiostyrene with t-butyllithium/TMEDA pentane led directly to (Z)-2-lithio-ortho-styryllithium. subsequent treatment of this dilithio compound with difunctional electrophiles allowed the preparation of a variety of benzoheteroles.

High-temperature synthesis of thiophene from bis(2-chloroethyl) sulfide

Gas-phase reaction of bis(2-chloroethyl) sulfide (Yperite) with acetylene at 550-700°C leads to formation of thiophene in 45% yield, the conversion of the initial sulfide being complete. The yield of thiophene reaches 63-68% in the thermolysis of a mixture of acetylene, bis(2-chloroethyl) sulfide, and lower organic disulfides.

Photolysis of β-(o-Methylthiophenyl)vinyl Bromides. A Versatile Synthesis of Benzothiophens

Exclusive cyclization in photolysis of β-(o-methylthiophenyl)vinyl bromides to give benzothiophens is described.

Ceramic boron carbonitrides for unlocking organic halides with visible light

Photochemistry provides a sustainable pathway for organic transformations by inducing radical intermediates from substrates through electron transfer process. However, progress is limited by heterogeneous photocatalysts that are required to be efficient, stable, and inexpensive for long-term operation with easy recyclability and product separation. Here, we report that boron carbonitride (BCN) ceramics are such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradiation. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds can proceed at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN can be used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst shows tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opens new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which are metal-free, inexpensive and stable. This journal is

Enantioselective hydroarylation or hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes

An efficient protocol for the asymmetric hydroarylation and hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes has been developed. The combination of a rhodium(I) precatalyst and a chiral diene ligand constitutes the catalytic system, which enables the facile synthesis of 2,3-dihydrobenzo[b]thiophene 1,1-dioxides in good yields with high enantioselectivities. The merging of this asymmetric hydroarylation with the downstream alkylations delivers 2,3-dihydrobenzo[b]thiophene 1,1-dioxides that contain two continuous quaternary stereocenters with high enantioselectivities in a diastereodivergent manner.