110973-39-2

Basic information

• Product Name: Naphtho[2,1-b]furan, 2-methyl-1-phenyl-
• CAS NO: 110973-39-2
• Molecular Formula: C19H14O
• Molecular Weight: 258.32
• Mol File: 110973-39-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Naphtho[2,1-b]furan, 2-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphtho[2,1-b]furan, 2-methyl-1-phenyl-(110973-39-2)
• EPA Substance Registry System: Naphtho[2,1-b]furan, 2-methyl-1-phenyl-(110973-39-2)

Safety Data

• Hazardous Substances Data: 110973-39-2(Hazardous Substances Data)

Upstream product

• 170700-64-8 2-[[(2E)-3-phenyl-2-propen-1-yl]oxy]naphthalene 
• 100-52-7 benzaldehyde 
• 633-99-8 1-chloro-2-naphthol 
• 573-97-7 1-bromo-2-naphthol 
• 4392-24-9 Cinnamyl bromide 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 135-19-3 β-naphthol 
• 1384158-31-9 C₂₂H₂₂OSi 
• 89530-34-7 1-phenyl-3-trimethylsilylprop-2-yn-1-ol 
• 705-60-2 1-phenyl-2-nitroprop-1-ene 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 

Relevant articles and documents

Facile synthesis of benzoindoles and naphthofurans through carbonaceous material-catalyzed cyclization of naphthylamines/naphthols with nitroolefins in water

A facile and efficient approach has been established for the synthesis of benzoindole and naphthofuran derivatives via the metal-free cyclization reaction of nitroolefins with naphthylamines/naphthols. Various substituted benzoindoles and naphthofurans are obtained in good to excellent yields. Moreover, the ability to recycle the carbonaceous material makes this method quite cost-effective and environmentally benign compared to traditional acid-catalyzed methods. Theoretical studies indicated that the reaction between naphthylamine and nitroolefin catalyzed by this solid acid was thermodynamically controlled at 60 °C, resulting in the formation of the benzoindoles.

: NBu4NPF6 promoted regioselective cascade synthesis of functionally embellished naphthofurans under acid, metal & solvent free conditions

nBu4NPF6 mediated highly regioselective synthesis of functionally embellished naphthofurans has been achieved from easily available naphthols and propargyl alcohols through a cascade benzylation, oxacyclisation (5-exo dig) and isomerization under solvent free conditions. The reaction works in a short time through dibenzyl ether formation followed by the decomposition to the carbocation to furnish the high yielding products with large substrate scope. The synthetic utility of the products is demonstrated through C(sp3)-H functionalization. In addition, we investigated selected naphthofurans for their anti-amyloidogenic properties. Preliminary studies suggest that these are excellent inhibitors for amyloid formation, a hallmark for several neurodegenerative diseases.

Diversified Synthesis of Furans by Coupling between Enols/1,3-Dicarbonyl Compounds and Nitroolefins: Direct Access to Dioxa[5]helicenes

A versatile method for the diversified synthesis of furans and arenofurans has been developed that proceeds through K2CO3-promoted cyclization between enols/1,3-dicarbonyl compounds and nitroolefins at reflux in EtOH. This facile method has been successfully employed in the synthesis of benzotrifuran derivatives, which are useful hole-transporting materials. This procedure also provides direct access to dioxa[5]helicenes. This reaction offers a broad substrate scope, uses an inexpensive base and environmentally benign solvent, and is operationally simple.