110997-07-4Relevant articles and documents
Catechol based inhibitors of 15-lipoxygenase
Tait, Bradley D.,Dyer, Richard D.,Auerbach, Bruce J.,Bornemeier, Dirk,Guilds-Zamarka, Linda,Oxender, Maritza,Roth, Bruce D.,Trivedi, Bharat K.,Cornicelli, Joseph A.
, p. 93 - 96 (2007/10/03)
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.
N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE
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, (2008/06/13)
The present invention relates to novel N-substituted 2-hydroxybenzamide and N-substituted 2-hydroxy-alpha-oxo-benezene acetamide compounds pharmaceutical compositions, and methods of use for therefore for the treatment of diseases in which products having lipoxygenase enzyme activity contribute to the pathological condition. Selected novel intermediates are also the present invention