110997-10-9Relevant articles and documents
Catechol based inhibitors of 15-lipoxygenase
Tait, Bradley D.,Dyer, Richard D.,Auerbach, Bruce J.,Bornemeier, Dirk,Guilds-Zamarka, Linda,Oxender, Maritza,Roth, Bruce D.,Trivedi, Bharat K.,Cornicelli, Joseph A.
, p. 93 - 96 (2007/10/03)
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.