111039-41-9Relevant articles and documents
Synthesis of difluoromethyl and deuterium-labeled difluoromethyl thioethers from aliphatic electrophiles
Ding, Tianqi,Jiang, Lvqi,Yi, Wenbin
, p. 3995 - 3998 (2020/04/17)
A one-pot difluoromethylthiolation of alkyl electrophiles with thiourea and diethyl bromodifluoromethylphosphonate is described. The transition-metal-free approach, readily available reagents, and mild conditions provide a practical way for the synthesis of difluoromethyl thioethers. By changing the "H" source to the most commonly used "D" sources CD3OD and D2O, this strategy enables efficient synthesis of SCF2D-substituted molecules in good yields with high levels of D incorporation.
Synthesis of 2-(Benzylthio)-4-(trifluoromethyl)thiazole-5-carboxylates Using S -Benzylisothiouronium Halides as Thiol Equivalents
Hickey, Shane M.,White, Jonathan M.,Pfeffer, Frederick M.,Ashton, Trent D.
supporting information, p. 1759 - 1763 (2015/07/20)
S-Benzylisothiouronium halides are used as shelf-stable, odorless thiol equivalents. The method developed is used to access 2-(benzylthio)-4-(trifluoromethyl)thiazole carboxyl building blocks. Using the latent trifluoromethyl substituent the reactions could be monitored using 19F NMR spectroscopy.
Synthesis and antimicrobial and nitric oxide synthase inhibitory activities of novel isothiourea derivatives
Kazimierczuk, Zygmunt,Chalimoniuk, Malgorzata,Laudy, Agnieszka Ewa,Moo-Puc, Rosa,Cedillo-Rivera, Roberto,Starosciak, Bohdan Jerzy,Chrapusta, Stanislaw J.
experimental part, p. 821 - 830 (2012/01/05)
The reaction of substituted benzylhalides, or of halomethyl derivatives of thiophene or furane, with thiourea or its derivatives yielded the respective isothioureas as hydrohalide salts. The products (a total of 17, including 16 novel compounds) were test
