111058-33-4Relevant articles and documents
Total Synthesis of Solandelactone i
Eichenauer, Nils C.,Tschersich, Roxanne,Pietruszka, J?rg
, p. 2782 - 2790 (2015)
Since the marine natural products solandelactones A-I were isolated from the hydroid Solanderia secunda and investigated by Seo et al. in 1996, considerable synthetic efforts toward these marine oxylipins followed. However, the structure elucidation of solandelactone I remained incomplete, and no synthesis has been reported. On the basis of our retrosynthetic analysis, the key building blocks were combined in a Horner-Wadsworth-Emmons reaction to create two common intermediates for the stereodivergent synthesis of all four diastereomers 1-4 matching the proposed structure of solandelactone I. Comparison of the published analytical data of natural product solandelactone I and data obtained from the synthetic endeavor toward diastereomers 1-4 enabled the structure assignment of isomer 3; the proposed biosynthetic pathway for marine oxylipins also supports the result.
SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME
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Paragraph 0605, (2019/02/15)
The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.
Ethyl glycidate from (S)-Serine: Ethyl (R)-(+)-2,3Epoxypropanoate: [Oxiranecarboxylic acid, ethyl ester, (R)-]
Petit,Peterson, Barry C.,Larchevêque,Roush, William R.
, p. 37 - 37 (2017/09/16)
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