111114-09-1Relevant articles and documents
Facile methods for the synthesis of 5-aryl and 5-iodo pyrrolo[2,3-d] pyrimidines
Venkata Rao,Raghu Prasad,Raghuram Rao
, p. E380-E383 (2014/11/07)
An efficient and environmentally benign one-pot method has been developed for the synthesis of 4-amino-5-arylpyrrolo[2,3-d]pyrimidines. Phthalimido acetophenones were reacted with cyanoacetamide to give 2-amino-4-phenyl-1H- pyrrole-3-carboxamides, which were further converted to 5-aryl-3H-pyrrolo[2,3-d] pyrimidin-4-ones. A novel method is also developed for the synthesis of 4-amino-5-iodopyrrolo[2,3-d]pyrimidines.
Ferric Chloride-Catalyzed Acylation of Aromatic Compounds with N-Phthaloyl-α-amino Acyl Chlorides without Racemisation
Effenberger, Franz,Steegmueller, Dieter
, p. 117 - 124 (2007/10/02)
Reactive aromatic compounds are acylated without racemisation to aryl 1-phthalimidoalkyl ketones 4 in good yields with N-phthaloyl-α-amino acid chlorides in the presence of catalytic amounts (1 to 5 mol-percent) of FeCl3.This new method is especially useful for the synthesis of the pharmacologically interesting alkoxyaryl 1-phthalimidoalkyl ketones 6, 8, 10, and 11, which cannot be prepared in reasonable yields in the presence of other FC catalysts such as AlCl3 or SnCl4.