1111637-74-1

Basic information

• Product Name: 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone
• Synonyms: 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone;1-(5-Bromo-2-fluoro-3-pyridinyl)ethanone;1-(5-Bromo-2-fluoropyridin-3-yl)ethan-1-one;3-Acetyl-5-bromo-2-fluoropyridine;Ethanone, 1-(5-broMo-2-fluoro-3-pyridinyl)-;1-(5-BroMo-2-fluoropyridine-3-yl)ethanone
• CAS NO: 1111637-74-1
• Molecular Formula: C7H5BrFNO
• Molecular Weight: 218.0231032
• EINECS: 1533716-785-6
• Product Categories: 1359703-93-7 oldold;MFCD21602878 oldold
• Mol File: 1111637-74-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 284.289 °C at 760 mmHg
• Flash Point: 125.734 °C
• Appearance: /
• Density: 1.62 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -4.58±0.20(Predicted)
• CAS DataBase Reference: 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone(1111637-74-1)
• EPA Substance Registry System: 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone(1111637-74-1)

Safety Data

• Hazardous Substances Data: 1111637-74-1(Hazardous Substances Data)

Usage

General Description

1-(5-Bromo-2-fluoropyridin-3-yl)ethanone is a chemical compound with the molecular formula C7H5BrFNO. It's characterized by the presence of a bromo and fluoro atom attached to a pyridine ring - a basic six-membered ring compound with one nitrogen atom, which is further linked to an ethanone group. 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone belongs to the family of aromatic organic compounds known as halopyridines. Specific information regarding its physical properties such as boiling and melting points, or its variety of applications are not extensively documented in the existing chemical literature. It's often used as an intermediate in various chemical reactions in laboratory and industrial settings.

Upstream product

• 766-11-0 5-bromo-2-fluoropyridine 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 875781-15-0 5-bromo-2-fluoro-3-pyridinecarboxaldehyde 
• 1111637-73-0 1-(5-bromo-2-fluoropyridin-3-yl)ethanol 

Downstream Products

• 916258-24-7 tert-butyl 5-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine-1-carboxylate 
• 1111637-76-3 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine 

Relevant articles and documents

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer

A novel series of pyridin-3-amine derivatives were designed, synthesized, and evaluated as multitargeted protein kinase inhibitors for the treatment of non-small cell lung cancer (NSCLC). Hit 1 was first disclosed by in silico screening against fibroblast

INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods o

AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.