1112-32-9 Usage
Description
(2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid, also known as alpha-ketoisocaproic acid or 2-KIC, is a keto acid derivative with the molecular formula C6H12O4. It serves as a key intermediate in the metabolism of the essential amino acid leucine and has been identified for its potential therapeutic applications in various diseases and conditions.
Uses
Used in Pharmaceutical Applications:
(2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid is used as a therapeutic agent for the treatment of conditions such as diabetes, kidney disease, and muscle wasting. Its role in the metabolism of leucine contributes to its potential benefits in these areas.
Used in Athletic Performance and Recovery:
(2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid is used as a performance enhancer and recovery aid in the sports and fitness industry. Its metabolic properties may contribute to improved athletic performance and faster recovery times for athletes.
Used in Neurological Disorder Treatment:
(2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid is used as a precursor in the production of the neurotransmitter GABA, which has implications for its potential use in the treatment of neurological disorders. Its involvement in neurotransmitter synthesis may offer therapeutic benefits for conditions related to neurotransmitter imbalances.
Used in Chemical Synthesis:
(2S)-2,4-Dihydroxy-3,3-dimethylbutanoic acid is used as a key intermediate in the synthesis of various chemical compounds, particularly in the pharmaceutical and chemical industries. Its unique structure makes it a valuable building block for the development of new drugs and other products.
Check Digit Verification of cas no
The CAS Registry Mumber 1112-32-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,1 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1112-32:
(6*1)+(5*1)+(4*1)+(3*2)+(2*3)+(1*2)=29
29 % 10 = 9
So 1112-32-9 is a valid CAS Registry Number.
1112-32-9Relevant articles and documents
Development of a Novel Biocatalyst for the Resolution of rac-Pantolactone
Kesseler, Maria,Friedrich, Thomas,Hoeffken, Hans Wolfgang,Hauer, Bernhard
, p. 1103 - 1110 (2007/10/03)
A novel L-pantolactone hydrolase, Lph, from Agrobacterium tumefaciens Lu681 was characterized, which stereospecifically hydrolyses L-pantolactone to L-pantoic acid yielding D-pantolactone with > 95% enantiomeric excess. The enzyme was found to be a 30 kDa-Zn2+-hydrolase with a Km for L-pantolactone of 7 mM and a Vmax of 30 U/mg. The corresponding lph gene was identified as an 807 bp ORF and cloned into E. coli. It was overexpressed under control of Ptac and Prha yielding enzyme activities of up to 600 U/g dry weight. Resolution of D,L-pantolactone in repeated batches with isolated Lph and enzyme recovery by membrane filtration gave D-pantolactone with 50% yield and 90-95% ee over 6 days. Covalent immobilization to EupergitC led to a stable biocatalyst easy to handle in a repeated batch production of D-pantolactone. Further improvements in the activity of Lph were achieved by directed evolution of the enzyme. Activities of mutants F62S, K197D and F100L were increased 2.3, 1.7, and 1.5 fold, respectively.
