1112-78-3Relevant articles and documents
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Lorette et al.
, p. 1731 (1959)
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Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles
Bonacorso, Helio G.,Martins, Marcos A.P.,Bittencourt, Sandra R.T.,Lourega, Rogerio V.,Zanatta, Nilo,Flores, Alex F.C.
, p. 177 - 182 (1999)
A convenient method to obtain β-alkyl-β-methoxyvinyl trifluoromethyl ketones [CF3COCHC(OMe)R, where R = Et, n-Pr, i-Pr, i-Bu, t-Bu, -(CH2)2OMe] from the regiospecific acylation of kinetic enol ether generated in situ is reported. The unsymmetrical ketone dimethyl acetals react with trifluoroacetic anhydride in the presence of pyridine using dry chloroform as solvent with a temperature range of 25-60°C. These acetals [R-C(OMe)2Me] are obtained from the reaction of alkyl methyl ketones with trimethyl orthoformate in the presence of p-toluenesulfonic acid as catalyst in pure methanol as solvent. The new acetylated enol ethers proved to be versatile building blocks for the construction of interesting alkyl trifluoromethyl substituted heterocycles. Thus, examples of isoxazoline, pyrazoline, pyrazole and pyrimidinone have been obtained in good yields (62-79%).
Zinc chloride as an efficient catalyst for chemoselective dimethyl acetalization
Roy, Anupam,Rahman, Matiur,Das, Sudarshan,Kundu, Dhiman,Kundu, Shrishnu Kumar,Majee, Adinath,Hajra, Alakananda
experimental part, p. 590 - 595 (2009/07/04)
Commercially available anhydrous zinc chloride has been found to be a highly efficient catalyst for dimethyl acetalization in high yields by treatment of aldehydes and ketones with trimethyl orthoformate in methanol-cyclohexane at reflux temperature. Copyright Taylor & Francis Group, LLC.
Cationic gold(I) complexes: Highly efficient catalysts for the addition of alcohols to alkynes
Teles, J. Henrique,Brode, Stefan,Chabanas, Mathieu
, p. 1415 - 1418 (2007/10/03)
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