1112983-31-9

Basic information

• Product Name: N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL]-4-FLUOROBENZENESULFONAMIDE
• Synonyms: N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL]-4-FLUOROBENZENESULFONAMIDE
• CAS NO: 1112983-31-9
• Molecular Weight: 412.677
• Mol File: 1112983-31-9.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL]-4-FLUOROBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL]-4-FLUOROBENZENESULFONAMIDE(1112983-31-9)
• EPA Substance Registry System: N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL]-4-FLUOROBENZENESULFONAMIDE(1112983-31-9)

Safety Data

• Hazardous Substances Data: 1112983-31-9(Hazardous Substances Data)

Usage

General Description

N-[2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL]-4-FLUOROBENZENESULFONAMIDE is a chemical compound with potential applications in pharmaceuticals, agrochemicals, and materials science. It is known for its unique structure, containing a boron-containing heterocycle and a fluorobenzene sulfonamide. The compound has shown potential as a candidate for drug discovery and development, particularly in the field of oncology and neurology. Its unique structure and biological activities make it an interesting molecule for further research and development in the field of medicinal chemistry and drug design.

Upstream product

• 588729-99-1 3-amino-5-bromo-2-chloropyridine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 1112982-79-2 N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide 
• 887309-87-7 N-(5-bromo-2-chloro-pyridine-3-yl)-4-fluorobenzenesulfonamide 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1162680-13-8 N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide 
• 1162680-37-6 N-(5-(2-aminoimidazo[1,2-a]pyridin-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1162680-35-4 N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide 
• 1162680-38-7 N-(5-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)acetamide 
• 1162680-41-2 N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)-1-(pyridin-2-yl)-1H-benzo[d]imidazol-2-yl)acetamide 
• 1162680-40-1 N-(5-(2-amino-1-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide formate 
• 1162680-58-1 N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide 
• 1312448-27-3 N-(5-(benzo[d]thiazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1313488-93-5 N-(5-(2-aminobenzo[d]oxazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1162680-45-6 N-(5-(2-aminoimidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1313488-94-6 N-(5-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1313488-90-2 N-(2-chloro-5-(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1313488-92-4 N-(5-(1H-benzo[d]imidazol-5-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1313488-89-9 N-(2-chloro-5-(imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 

Relevant articles and documents

Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation

Breast cancer is the cancer with the highest incidence all over the world. Phosphatidylinositol 3-kinase is an important regulator of intracellular signaling pathways, which is frequently mutated and overexpressed in majority of human breast cancers, and the inhibition of PI3K has been considered as a promising approach for the treatment of the cancer. Here, we report our design and synthesis of new 7-azaindole derivatives as PI3K inhibitors through the scaffold hopping strategy. By varying the groups at the 3-position of 7-azaindole, we identified a series of potent PI3K inhibitors, whose antiproliferative activities against two human breast cancer MCF-7 and MDA-MB-231 cell lines were evaluated. Representative derivatives FD2054 and FD2078 showed better activity than BKM120 in antiproliferation, reduced the levels of phospho-AKT and induced cell apoptosis. All these results suggested that FD2054 and FD2078 are potent PI3K inhibitors that could be considered as potential candidates for the development of anticancer agents.

Discovery of new thienopyrimidine derivatives as potent and orally efficacious phosphoinositide 3-kinase inhibitors

A series of new thienopyrimidine derivatives has been discovered as potent PI3K inhibitors. The systematic SAR studies for these analogues are described. Among them, 8a and 9a exhibit nanomolar enzymatic potencies and sub-micromolar cellular anti-prolifer

Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity

The phosphoinositide 3-kinase (PI3K) inhibitors potently inhibit the signaling pathway of PI3K/AKT/mTOR, which provides a promising new approach for the molecularly targeted cancer therapy. In this work, a novel series of 7-azaindole scaffold derivatives was discovered by the fragment-based growing strategy. The structure-activity relationship profiles identified that the 7-azaindole scaffold derivatives exhibit potent activity against PI3K at molecular and cellular levels as well as cell proliferation in a panel of human tumor cells.