111316-17-7

Basic information

• Product Name: 1-Propanone, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-
• CAS NO: 111316-17-7
• Molecular Formula: C16H16O5
• Molecular Weight: 288.3
• Mol File: 111316-17-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-(111316-17-7)
• EPA Substance Registry System: 1-Propanone, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-(4-hydroxyphenyl)-(111316-17-7)

Safety Data

• Hazardous Substances Data: 111316-17-7(Hazardous Substances Data)

Usage

Molecular Structure

A derivative of propanone with two hydroxyl groups (-OH) and one methoxy group (-OCH3) attached to a phenyl ring, with another phenyl ring attached to one of the hydroxyl groups.

Usage

Used in the production of various cosmetic and skincare products as a skin-lightening agent.

Mechanism of Action

Inhibits the production of melanin in the skin, resulting in a lighter complexion.

Adverse Effects

Skin depigmentation and inflammation.

Safety Concerns

Use of rhododendrol in cosmetic products has been banned in several countries due to serious adverse effects.

Research Needs

Further research is needed to fully understand the potential risks associated with the use of this chemical in skincare products.

Upstream product

• 60-82-2 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on 
• 77-78-1 dimethyl sulfate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 39548-89-5 1-(4-(benzyloxy)-2-hydroxy-6-methoxyphenyl)ethan-1-one 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 18916-17-1 [4-[[2-O-(6-deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone 
• 10236-47-2 naringin 
• 2174-64-3 5-methoxyresorcinol 
• 17362-17-3 3-(p-hydroxyphenyl)propiononitrile 

Relevant articles and documents

Dihydrochalcones: Evaluation as novel radical scavenging antioxidants

Dihydrochalcones are a family of bicyclic flavonoids, defined by the presence of two benzene rings joined by a saturated three carbon bridge. In the present study, we systematically examined the antioxidant activities of dihydrochalcones against the stable free radical (1,1-diphenyl-2-picrylhydrazyl) and lipid peroxidation in the erythrocyte membrane. All dihydrochalcones exhibited higher antioxidant activities than the corresponding flavanones. The 1H NMR analysis indicated that the active dihydrochalcone has a time-averaged conformation in which the aromatic A ring is orthogonal to the carbonyl group, while the inactive dihydrochalcone such as 2′-O-methyl-phloretin has a strongly hydrogen-bonded phenolic hydroxyl group, suggestive of a coplanar conformation. A hydroxyl group at the 2′-position of the dihydrochalcone A ring, newly formed by reduction of the flavanone C ring, is an essential pharmacophore for its radical scavenging potential.

Synthesis, crystal structure, and biological evaluation of a series of phloretin derivatives

A one-step synthesis of phloretin derivatives 2-11 from phloretin in good to excellent yields is reported. Their structures were characterized by 1H-NMR, 13C-NMR and MS, and the structures of 8 and 11 were determined by X-ray diffrac