1114573-37-3

Basic information

• Product Name: 3-[(S)-1-(4'-amino-3'-nitrobiphenyl-4-yl)ethyl]-(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-[1,3]oxazinan-2-one
• Synonyms: 3-[(S)-1-(4'-amino-3'-nitrobiphenyl-4-yl)ethyl]-(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-[1,3]oxazinan-2-one
• CAS NO: 1114573-37-3
• Molecular Weight: 489.571
• Mol File: 1114573-37-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[(S)-1-(4'-amino-3'-nitrobiphenyl-4-yl)ethyl]-(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-[1,3]oxazinan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(S)-1-(4'-amino-3'-nitrobiphenyl-4-yl)ethyl]-(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-[1,3]oxazinan-2-one(1114573-37-3)
• EPA Substance Registry System: 3-[(S)-1-(4'-amino-3'-nitrobiphenyl-4-yl)ethyl]-(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-[1,3]oxazinan-2-one(1114573-37-3)

Safety Data

• Hazardous Substances Data: 1114573-37-3(Hazardous Substances Data)

Upstream product

• 833486-94-5 4-amino-3-nitrophenylboronic acid pinacol ester 
• 1110641-70-7 (S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one 

Downstream Products

• 1114573-67-9 (S)-6-(2-Hydroxy-2-methyl-propyl)-3-{(S)-1-[4-(2-methyl-3H-benzoimidazol-5-yl)-phenyl]-ethyl}-6-phenyl-[1,3]oxazinan-2-one 
• 1114573-38-4 3-[(S)-1-(3',4'-diaminobiphenyl-4-yl)ethyl]-(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl[1,3]oxazinan-2-one 

Relevant articles and documents

INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1

This invention relates to novel compounds of the Formula (I), (Ia1-10), (Ib1-10), (Ic1-10), (Id1-7), (Ie1-5) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.