111470-37-2Relevant articles and documents
Asymmetric synthesis of ABC tricyclic core in Daphniphyllum alkaloid 21-deoxy-macropodumine D
Mo, Xiu-Fang,Li, Yun-Fei,Sun, Ming-Hui,Dong, Qiu-Yan,Xie, Qin-Xia,Tang, Pei,Xue, Fei,Qin, Yong
, p. 1999 - 2004 (2018)
In this paper, we describe our efforts toward the asymmetric synthesis of Daphniphyllum alkaloid 21-deoxymacropodumine D which led to efficient preparation of a ABC tricyclic framework containing five consecutive stereocenters. This synthetic work features (1) utilization of an asymmetric conjugate addition to install the C5 all-carbon quaternary center, (2) an intramolecular aza-Michael addition followed by Pd-catalyzed α-alkenylation to build the bowl-shaped tricyclic core.
Intramolecular Additions of Allylsilanes to Conjugated Dienones. The Synthesis of Three Perforanes
Majetich, George,Defauw, Jean,Ringold, Clay
, p. 50 - 68 (2007/10/02)
Intramolecular addition of allylsilanes to 3-vinylcycloalkenones provides a powerful means of constructing functionalized 5-5, 5-7, 6-5, and 6-7 bicyclic ring systems.Our results reveal a divergence in reactivity, dependent on reaction catalyst and substr
