111570-97-9

Basic information

• Product Name: 1,1-dimethyl-2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N,N-diisopropylphosphoramidite
• CAS NO: 111570-97-9
• Molecular Weight: 772.879
• Mol File: 111570-97-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-dimethyl-2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N,N-diisopropylphosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-dimethyl-2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N,N-diisopropylphosphoramidite(111570-97-9)
• EPA Substance Registry System: 1,1-dimethyl-2-cyanoethyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl N,N-diisopropylphosphoramidite(111570-97-9)

Safety Data

• Hazardous Substances Data: 111570-97-9(Hazardous Substances Data)

Upstream product

• 13635-04-6 3-hydroxy-3-methylbutyronitrile 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 103930-70-7 (i-Pr₂N)2POC(CH₃)2CH₂CN 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Relevant articles and documents

Sulfurization of dinucleoside phosphite triesters with chiral disulfides

Sixteen chiral analogues of phenylacetyl disulfide (PADS) and 5-methyl-3H-1,2,4-dithiazol-3-one (MEDITH) were used to sulfurize five dithymidine phosphite triesters, each incorporating a β-cyanoethoxy or siloxy group. Each mixture of SP:RP phosphite triester diastereomers was combined with approximately one fourth of an equivalent of each of the sulfurizing reagents, and the RPS:SPS diastereomer ratios of the resulting phosphite sulfides or phosphorothioates were determined by reverse-phase HPLC. Diastereoselectivities and corresponding diastereomeric excess (de) values were calculated by correcting for the starting triester diastereomer ratios. The highest de values for RPS and SPS phosphorothioates were 14.7% and 7.9%, respectively, both using MEDITH analogues. Copyright Taylor and Francis Group, LLC.