1116086-49-7

Basic information

• Product Name: (R)-flurbiprofen di(1-naphthyl)methyl ester
• Synonyms: (R)-flurbiprofen di(1-naphthyl)methyl ester
• CAS NO: 1116086-49-7
• Molecular Weight: 510.608
• Mol File: 1116086-49-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-flurbiprofen di(1-naphthyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-flurbiprofen di(1-naphthyl)methyl ester(1116086-49-7)
• EPA Substance Registry System: (R)-flurbiprofen di(1-naphthyl)methyl ester(1116086-49-7)

Safety Data

• Hazardous Substances Data: 1116086-49-7(Hazardous Substances Data)

Upstream product

• 5104-49-4 fluorobiprofen 
• 62784-66-1 bis(1-naphthyl)methanol 
• 185981-25-3 C₃₀H₂₄F₂O₃ 

Relevant articles and documents

Method for manufacturing optically active carboxylic acid ester

A method that manufacturers an optically active carboxylic acid ester at high yield and high enantioselectivity is provided. An optically active carboxylic acid ester is manufactured at high yield and high enantioselectivity by reacting a racemic carboxyl

METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID

Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically active ester is produced while producing an optically active carboxylic acid at the same time by reacting a racemic carboxylic acid with a specific alcohol or phenol derivative in the presence of benzoic anhydride or a derivative thereof and a catalyst such as tetramisole or benzotetramisole, thereby selectively esterifying one enantiomer of the racemic carboxylic acid.

Kinetic resolution of racemic carboxylic acids using achiral alcohols by the promotion of benzoic anhydrides and tetramisole derivatives: Production of chiral nonsteroidal anti-inflammatory drugs and their esters

A variety of optically active carboxylic esters were produced by kinetic resolution of racemic carboxylic acids by using achiral alcohols, benzoic anhydrides, and Birman's tetramisole-type catalysts. Bis(α-naphthyl) methanol is a very effective reagent for producing the corresponding esters with high ee values in the presence of 4-methoxybenzoic anhydride (PMBA) as the coupling reagent by promotion of benzotetramisole derivatives (BTM, α-Np-BTM, and β-Np-BTM). This protocol directly provides chiral carboxylic esters from free carboxylic acids and achiral alcohols by utilizing a transacylation process to generate the mixed anhydrides from the acid components with benzoic anhydride derivatives in the presence of chiral catalysts. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.