1116088-85-7Relevant articles and documents
Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue
Ma, Yao,Yin, Dawei,Ye, Jingjia,Wei, Xiduan,Pei, Yameng,Li, Xueyuan,Si, Guangxu,Chen, Xuan-Yu,Chen, Zhe-Sheng,Dong, Yi,Zou, Feng,Shi, Wei,Qiu, Qianqian,Qian, Hai,Liu, Gang
, p. 5458 - 5476 (2020/06/10)
SIS3 is a specific inhibitor of Smad3 that inhibits the TGFβ1-induced phosphorylation of Smad3. In this article, a variety of SIS3 derivatives were designed and synthesized to discover potential inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of a 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue. A novel class of potent P-gp reversal agents were investigated, and a lead compound 37 was identified as a potent P-gp reversal agent with strong bioactivity and outstanding affinity for P-gp.
Pd/Cu-catalyzed oxidative C-H alkenylation of imidazo[1,2-α]pyridines
Koubachi, Jamal,Berteina-Raboin, Sabine,Mouaddib, Abderrahim,Guillaumet, Gerald
scheme or table, p. 271 - 276 (2009/06/27)
A novel direct and regioselective Pd/Cu-catalyzed intermolecular oxidative coupling of imidazo[1,2-α]pyridines with alkenes was successfully developed. The scope and limitations of the reaction were further studied by using various alkenes. This method pr
